Transforming growth factor-beta1 in the urine of young children with urinary tract infection

Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2005-02, Vol.20 (2), p.180-183
Main Authors: Farmaki, Evangelia, Papachristou, Fotis, Winn, Richard M, Karatzas, Nicolas, Sotiriou, John, Roilides, Emmanuel
Format: Article
Language:English
Subjects:
Child, Preschool
Female
Fibrosis - immunology
Humans
Infant
Male
Pyelonephritis - immunology
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta1
Urinary Tract Infections - complications
Urinary Tract Infections - immunology
Urinary Tract Infections - urine
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Summary:Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P
ISSN:0931-041X