Transforming growth factor-beta1 in the urine of young children with urinary tract infection

Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2005-02, Vol.20 (2), p.180-183
Main Authors: Farmaki, Evangelia, Papachristou, Fotis, Winn, Richard M, Karatzas, Nicolas, Sotiriou, John, Roilides, Emmanuel
Format: Article
Language:English
Subjects:
Child, Preschool
Female
Fibrosis - immunology
Humans
Infant
Male
Pyelonephritis - immunology
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta1
Urinary Tract Infections - complications
Urinary Tract Infections - immunology
Urinary Tract Infections - urine
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 183
container_issue 2
container_start_page 180
container_title Pediatric nephrology (Berlin, West)
container_volume 20
creator Farmaki, Evangelia
Papachristou, Fotis
Winn, Richard M
Karatzas, Nicolas
Sotiriou, John
Roilides, Emmanuel
description Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67380670</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67380670</sourcerecordid><originalsourceid>FETCH-LOGICAL-p541-8a4eb56a5c6602cc9191405b3e97a1f70ba718d25afef711c488b182745c24953</originalsourceid><addsrcrecordid>eNo1kD1PwzAURT2AaCn8BeSJLZJfYsf2iCq-JCSWDgxIkeM-t0aJXWxHVf89QZTpDfecq6t3QZZMN1AxDh8Lcp3zF2NMCdVekQUIobWUsCSfm2RCdjGNPuzoLsVj2VNnbImp6rEYoD7Qskc6JR-QRkdPcZpJu_fDNmGgRz8Lv6FJJ1rSbM6GQ1t8DDfk0pkh4-35rsjm6XGzfqne3p9f1w9v1UFwqJTh2IvWCNu2rLZWgwbORN-glgacZL2RoLa1MA6dBLBcqR5ULbmwNdeiWZH7v9pDit8T5tKNPlscBhMwTrlrZaNYK9kM3p3BqR9x2x2SH-fZ3f87mh-l81uI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67380670</pqid></control><display><type>article</type><title>Transforming growth factor-beta1 in the urine of young children with urinary tract infection</title><source>Springer Nature</source><creator>Farmaki, Evangelia ; Papachristou, Fotis ; Winn, Richard M ; Karatzas, Nicolas ; Sotiriou, John ; Roilides, Emmanuel</creator><creatorcontrib>Farmaki, Evangelia ; Papachristou, Fotis ; Winn, Richard M ; Karatzas, Nicolas ; Sotiriou, John ; Roilides, Emmanuel</creatorcontrib><description>Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P&lt;0.001). TGF-beta was detected in the urine only during the early stage (&lt;1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal (99m )Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.</description><identifier>ISSN: 0931-041X</identifier><identifier>PMID: 15599771</identifier><language>eng</language><publisher>Germany</publisher><subject>Child, Preschool ; Female ; Fibrosis - immunology ; Humans ; Infant ; Male ; Pyelonephritis - immunology ; Transforming Growth Factor beta - analysis ; Transforming Growth Factor beta - immunology ; Transforming Growth Factor beta1 ; Urinary Tract Infections - complications ; Urinary Tract Infections - immunology ; Urinary Tract Infections - urine</subject><ispartof>Pediatric nephrology (Berlin, West), 2005-02, Vol.20 (2), p.180-183</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15599771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farmaki, Evangelia</creatorcontrib><creatorcontrib>Papachristou, Fotis</creatorcontrib><creatorcontrib>Winn, Richard M</creatorcontrib><creatorcontrib>Karatzas, Nicolas</creatorcontrib><creatorcontrib>Sotiriou, John</creatorcontrib><creatorcontrib>Roilides, Emmanuel</creatorcontrib><title>Transforming growth factor-beta1 in the urine of young children with urinary tract infection</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P&lt;0.001). TGF-beta was detected in the urine only during the early stage (&lt;1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal (99m )Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.</description><subject>Child, Preschool</subject><subject>Female</subject><subject>Fibrosis - immunology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Pyelonephritis - immunology</subject><subject>Transforming Growth Factor beta - analysis</subject><subject>Transforming Growth Factor beta - immunology</subject><subject>Transforming Growth Factor beta1</subject><subject>Urinary Tract Infections - complications</subject><subject>Urinary Tract Infections - immunology</subject><subject>Urinary Tract Infections - urine</subject><issn>0931-041X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNo1kD1PwzAURT2AaCn8BeSJLZJfYsf2iCq-JCSWDgxIkeM-t0aJXWxHVf89QZTpDfecq6t3QZZMN1AxDh8Lcp3zF2NMCdVekQUIobWUsCSfm2RCdjGNPuzoLsVj2VNnbImp6rEYoD7Qskc6JR-QRkdPcZpJu_fDNmGgRz8Lv6FJJ1rSbM6GQ1t8DDfk0pkh4-35rsjm6XGzfqne3p9f1w9v1UFwqJTh2IvWCNu2rLZWgwbORN-glgacZL2RoLa1MA6dBLBcqR5ULbmwNdeiWZH7v9pDit8T5tKNPlscBhMwTrlrZaNYK9kM3p3BqR9x2x2SH-fZ3f87mh-l81uI</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Farmaki, Evangelia</creator><creator>Papachristou, Fotis</creator><creator>Winn, Richard M</creator><creator>Karatzas, Nicolas</creator><creator>Sotiriou, John</creator><creator>Roilides, Emmanuel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Transforming growth factor-beta1 in the urine of young children with urinary tract infection</title><author>Farmaki, Evangelia ; Papachristou, Fotis ; Winn, Richard M ; Karatzas, Nicolas ; Sotiriou, John ; Roilides, Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p541-8a4eb56a5c6602cc9191405b3e97a1f70ba718d25afef711c488b182745c24953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Child, Preschool</topic><topic>Female</topic><topic>Fibrosis - immunology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Pyelonephritis - immunology</topic><topic>Transforming Growth Factor beta - analysis</topic><topic>Transforming Growth Factor beta - immunology</topic><topic>Transforming Growth Factor beta1</topic><topic>Urinary Tract Infections - complications</topic><topic>Urinary Tract Infections - immunology</topic><topic>Urinary Tract Infections - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farmaki, Evangelia</creatorcontrib><creatorcontrib>Papachristou, Fotis</creatorcontrib><creatorcontrib>Winn, Richard M</creatorcontrib><creatorcontrib>Karatzas, Nicolas</creatorcontrib><creatorcontrib>Sotiriou, John</creatorcontrib><creatorcontrib>Roilides, Emmanuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farmaki, Evangelia</au><au>Papachristou, Fotis</au><au>Winn, Richard M</au><au>Karatzas, Nicolas</au><au>Sotiriou, John</au><au>Roilides, Emmanuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming growth factor-beta1 in the urine of young children with urinary tract infection</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>20</volume><issue>2</issue><spage>180</spage><epage>183</epage><pages>180-183</pages><issn>0931-041X</issn><abstract>Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P&lt;0.001). TGF-beta was detected in the urine only during the early stage (&lt;1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal (99m )Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.</abstract><cop>Germany</cop><pmid>15599771</pmid><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0931-041X
ispartof Pediatric nephrology (Berlin, West), 2005-02, Vol.20 (2), p.180-183
issn 0931-041X
language eng
recordid cdi_proquest_miscellaneous_67380670
source Springer Nature
subjects Child, Preschool
Female
Fibrosis - immunology
Humans
Infant
Male
Pyelonephritis - immunology
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta1
Urinary Tract Infections - complications
Urinary Tract Infections - immunology
Urinary Tract Infections - urine
title Transforming growth factor-beta1 in the urine of young children with urinary tract infection
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A28%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transforming%20growth%20factor-beta1%20in%20the%20urine%20of%20young%20children%20with%20urinary%20tract%20infection&rft.jtitle=Pediatric%20nephrology%20(Berlin,%20West)&rft.au=Farmaki,%20Evangelia&rft.date=2005-02&rft.volume=20&rft.issue=2&rft.spage=180&rft.epage=183&rft.pages=180-183&rft.issn=0931-041X&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E67380670%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p541-8a4eb56a5c6602cc9191405b3e97a1f70ba718d25afef711c488b182745c24953%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=67380670&rft_id=info:pmid/15599771&rfr_iscdi=true