Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node

We treated 6 patients with recurrent oral cancer and metastasis to the cervical lymph nodes after conventional treatments in 5 and non-conventional in 1 using BNCT, and herein report our results. The clinical response in our patients ranged from CR to PD. In 5 cases, spontaneous pain decreased immed...

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-07, Vol.67 (7), p.S47-S49
Main Authors: Kimura, Y., Ariyoshi, Y., Shimahara, M., Miyatake, S., Kawabata, S., Ono, K., Suzuki, M., Maruhashi, A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Boron Compounds - therapeutic use
Boron Neutron Capture Therapy
Boron neutron capture therapy (BNCT)
Boronophenylalanine (BPA)
Female
Fluorine Radioisotopes
Humans
Lymphatic Metastasis - diagnostic imaging
Lymphatic Metastasis - radiotherapy
Male
Middle Aged
Mouth Neoplasms - diagnostic imaging
Mouth Neoplasms - physiopathology
Mouth Neoplasms - radiotherapy
Neck
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - physiopathology
Neoplasm Recurrence, Local - radiotherapy
Oral cancer
Pain - physiopathology
Phenylalanine - analogs & derivatives
Phenylalanine - therapeutic use
Positron-Emission Tomography
Quality of Life
Radiation-Sensitizing Agents - therapeutic use
Radiopharmaceuticals
Tomography, X-Ray Computed
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Description
Summary:We treated 6 patients with recurrent oral cancer and metastasis to the cervical lymph nodes after conventional treatments in 5 and non-conventional in 1 using BNCT, and herein report our results. The clinical response in our patients ranged from CR to PD. In 5 cases, spontaneous pain decreased immediately after BNCT. Three of the 6 are alive at the time of writing and we found that BNCT contributed to QOL improvement in all.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.03.019