Blood Pressure Response to Strength Training May Be Influenced by Angiotensinogen A-20C and Angiotensin II Type I Receptor A1166C Genotypes in Older Men and Women

Objectives: To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Design: Prospective intervention study with retrospective genotyping. S...

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Published in:Journal of the American Geriatrics Society (JAGS) 2005-02, Vol.53 (2), p.204-210
Main Authors: Delmonico, Matthew J., Ferrell, Robert E., Meerasahib, Anish, Martel, Greg F., Roth, Stephen M., Kostek, Matthew C., Hurley, Ben F.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
Angiotensinogen - genetics
Biological and medical sciences
Blood pressure
Blood Pressure - genetics
Body Composition
Exercise
Exercise - physiology
Female
General aspects
Genotype
Genotype & phenotype
Humans
hypertension
Male
Medical sciences
Middle Aged
Muscle, Skeletal - physiology
Older people
Physical Endurance - genetics
Polymorphism, Genetic
Proteins
Receptor, Angiotensin, Type 1 - genetics
single nucleotide polymorphism
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cited_by cdi_FETCH-LOGICAL-c4944-10da87aa72b189b551d627a61fcea53e7735e00d3eb50287e813d43203bb5b63
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container_issue 2
container_start_page 204
container_title Journal of the American Geriatrics Society (JAGS)
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creator Delmonico, Matthew J.
Ferrell, Robert E.
Meerasahib, Anish
Martel, Greg F.
Roth, Stephen M.
Kostek, Matthew C.
Hurley, Ben F.
description Objectives: To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Design: Prospective intervention study with retrospective genotyping. Setting: University of Maryland Exercise Physiology Laboratory. Participants: Seventy sedentary, healthy older men (n=34) and women (n=36). Intervention: Approximately 23 weeks of ST performed 3 days per week. Measurements: Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid. Results: Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg, P
doi_str_mv 10.1111/j.1532-5415.2005.53104.x
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Design: Prospective intervention study with retrospective genotyping. Setting: University of Maryland Exercise Physiology Laboratory. Participants: Seventy sedentary, healthy older men (n=34) and women (n=36). Intervention: Approximately 23 weeks of ST performed 3 days per week. Measurements: Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid. Results: Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg, P&lt;.05), which was significantly greater than the decrease in the A homozygotes (126±1 to 123±1 mmHg, P&lt;.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C‐allele carriers (76±1 to 70±2 mmHg, P&lt;.05) than in the A homozygotes (75±1 to 72±1 mmHg, P&lt;.05). Conclusion: The AGT A–20C and AGTR1 A1166C genotypes may influence resting BP response to ST, such that C‐allele carriers at each of these loci reduce their resting BP in response to ST to a greater extent than A homozygotes.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2005.53104.x</identifier><identifier>PMID: 15673342</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Aged ; Aged, 80 and over ; aging ; Angiotensinogen - genetics ; Biological and medical sciences ; Blood pressure ; Blood Pressure - genetics ; Body Composition ; Exercise ; Exercise - physiology ; Female ; General aspects ; Genotype ; Genotype &amp; phenotype ; Humans ; hypertension ; Male ; Medical sciences ; Middle Aged ; Muscle, Skeletal - physiology ; Older people ; Physical Endurance - genetics ; Polymorphism, Genetic ; Proteins ; Receptor, Angiotensin, Type 1 - genetics ; single nucleotide polymorphism</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2005-02, Vol.53 (2), p.204-210</ispartof><rights>2005 INIST-CNRS</rights><rights>2005 by the American Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4944-10da87aa72b189b551d627a61fcea53e7735e00d3eb50287e813d43203bb5b63</citedby><cites>FETCH-LOGICAL-c4944-10da87aa72b189b551d627a61fcea53e7735e00d3eb50287e813d43203bb5b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16627406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15673342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delmonico, Matthew J.</creatorcontrib><creatorcontrib>Ferrell, Robert E.</creatorcontrib><creatorcontrib>Meerasahib, Anish</creatorcontrib><creatorcontrib>Martel, Greg F.</creatorcontrib><creatorcontrib>Roth, Stephen M.</creatorcontrib><creatorcontrib>Kostek, Matthew C.</creatorcontrib><creatorcontrib>Hurley, Ben F.</creatorcontrib><title>Blood Pressure Response to Strength Training May Be Influenced by Angiotensinogen A-20C and Angiotensin II Type I Receptor A1166C Genotypes in Older Men and Women</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives: To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Design: Prospective intervention study with retrospective genotyping. Setting: University of Maryland Exercise Physiology Laboratory. Participants: Seventy sedentary, healthy older men (n=34) and women (n=36). Intervention: Approximately 23 weeks of ST performed 3 days per week. Measurements: Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid. Results: Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg, P&lt;.05), which was significantly greater than the decrease in the A homozygotes (126±1 to 123±1 mmHg, P&lt;.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C‐allele carriers (76±1 to 70±2 mmHg, P&lt;.05) than in the A homozygotes (75±1 to 72±1 mmHg, P&lt;.05). 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Design: Prospective intervention study with retrospective genotyping. Setting: University of Maryland Exercise Physiology Laboratory. Participants: Seventy sedentary, healthy older men (n=34) and women (n=36). Intervention: Approximately 23 weeks of ST performed 3 days per week. Measurements: Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid. Results: Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg, P&lt;.05), which was significantly greater than the decrease in the A homozygotes (126±1 to 123±1 mmHg, P&lt;.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C‐allele carriers (76±1 to 70±2 mmHg, P&lt;.05) than in the A homozygotes (75±1 to 72±1 mmHg, P&lt;.05). Conclusion: The AGT A–20C and AGTR1 A1166C genotypes may influence resting BP response to ST, such that C‐allele carriers at each of these loci reduce their resting BP in response to ST to a greater extent than A homozygotes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>15673342</pmid><doi>10.1111/j.1532-5415.2005.53104.x</doi><tpages>7</tpages></addata></record>
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subjects Aged
Aged, 80 and over
aging
Angiotensinogen - genetics
Biological and medical sciences
Blood pressure
Blood Pressure - genetics
Body Composition
Exercise
Exercise - physiology
Female
General aspects
Genotype
Genotype & phenotype
Humans
hypertension
Male
Medical sciences
Middle Aged
Muscle, Skeletal - physiology
Older people
Physical Endurance - genetics
Polymorphism, Genetic
Proteins
Receptor, Angiotensin, Type 1 - genetics
single nucleotide polymorphism
title Blood Pressure Response to Strength Training May Be Influenced by Angiotensinogen A-20C and Angiotensin II Type I Receptor A1166C Genotypes in Older Men and Women
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