The mannose receptor: linking homeostasis and immunity through sugar recognition

The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surp...

Full description

Saved in:
Bibliographic Details
Published in:Trends in immunology 2005-02, Vol.26 (2), p.104-110
Main Authors: Taylor, Philip R., Gordon, Siamon, Martinez-Pomares, Luisa
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - physiology
Binding Sites - physiology
Carbohydrate Metabolism
Cell Adhesion - physiology
Dendritic Cells - physiology
Gene Expression Regulation
Homeostasis - physiology
Humans
Immunity - physiology
Lectins, C-Type - chemistry
Lectins, C-Type - genetics
Lectins, C-Type - physiology
Luteinizing Hormone - metabolism
Macrophage Activation - physiology
Macrophages - physiology
Mannose-Binding Lectins - chemistry
Mannose-Binding Lectins - genetics
Mannose-Binding Lectins - physiology
Models, Biological
Models, Molecular
Phagocytosis - physiology
Protein Conformation
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2004.12.001