Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia

• Published in: The journal of obstetrics and gynaecology research 2005-02, Vol.31 (1), p.72-77
• Main Authors: Fukushima, Akimune, Kawahara, Hisao, Isurugi, Chizuko, Syoji, Tadahiro, Oyama, Rie, Sugiyama, Toru, Horiuchi, Saburo
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Case-Control Studies; Female; Gestational Age; heat shock protein 70; HSP70 Heat-Shock Proteins - blood; Humans; Obstetric Labor, Premature - blood; Parity; pre-eclampsia; Pre-Eclampsia - blood; Predictive Value of Tests; Pregnancy; Pregnancy Trimesters - blood; preterm delivery
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/j.1447-0756.2005.00244.x

Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia. Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐risk patients with a tocolysis index of three points or above (A), seven pre‐eclampsia patients (P), 46 normal pregnant women (B), and seven non‐pregnant women (C). Of the 31 preterm delivery high‐risk patients, 15 had preterm delivery (Ap) and 16 had full‐term delivery (Af ). The levels of Hsp70 were measured using enzyme‐linked immunosorbent assay. Results: The Hsp70 levels in normal pregnant women were 8.6 ± 1.9 ng/mL (first trimester), 5.5 ± 1.0 ng/mL (second trimester) and 5.5 ± 0.7 ng/mL (third trimester). There was no statistical difference in the Hsp70 levels between the three trimesters. The mean Hsp70 levels were 21.9 ± 5.3 ng/mL (A), 35.3 ± 9.6 ng/mL (Ap), 9.4 ± 2.2 ng/mL (Af), 24.4 ± 3.6 ng/mL (P), 6.1 ± 0.6 ng/mL (B), and 2.4 ± 0.6 ng/mL (C). Group Ap had significantly higher Hsp70 levels than group Af (P = 0.0112) and group B (P