Effect of Glycine on the Microcirculation in Rat Mesenteric Vessels

Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-03, Vol.147 (3), p.308-311
Main Authors: Podoprigora, G. I, Nartsissov, Ya. R
Format: Article
Language:English
Subjects:
Animals
Arterioles - drug effects
Biomedical and Life Sciences
Biomedicine
biomicroscopy
Cell Biology
General Pathology and Pathological Physiology
glycine
Glycine - pharmacology
histamine
Histamine - pharmacology
Internal Medicine
Laboratory Medicine
Male
Mesenteric Arteries - drug effects
mesenteric arterioles
microcirculation
Microcirculation - drug effects
Microvessels - drug effects
Pathology
Rats
Rats, Wistar
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the mesenteric surface was followed by arteriolar dilation (by 50-80%). Histamine-induced disturbances in the microcirculation were not observed after preapplication of glycine. Under these conditions, pretreatment with histamine was accompanied by reversible changes. Our results suggest that the natural metabolite glycine has a prophylactic and therapeutic effect on microcirculatory disturbances, which are induced by inflammatory-and-allergic mediator histamine.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0498-y