Comparison of BNCT and GdNCT efficacy in treatment of canine cancer

In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as...

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-07, Vol.67 (7), p.S299-S301
Main Authors: Mitin, V.N., Kulakov, V.N., Khokhlov, V.F., Sheino, I.N., Arnopolskaya, A.M., Kozlovskaya, N.G., Zaitsev, K.N., Portnov, A.A.
Format: Article
Language:English
Subjects:
Animals
Bone Neoplasms - radiotherapy
Bone Neoplasms - veterinary
Boron Compounds - therapeutic use
Boron NCT
Boron Neutron Capture Therapy - veterinary
Combined Modality Therapy
Dog Diseases - radiotherapy
Dog Diseases - therapy
Dogs
Gadolinium - therapeutic use
Gadolinium NCT
Humans
Melanoma
Melanoma - radiotherapy
Melanoma - veterinary
Mouth Neoplasms - radiotherapy
Mouth Neoplasms - veterinary
Neoplasms - radiotherapy
Neoplasms - therapy
Neoplasms - veterinary
Neutron Capture Therapy - veterinary
Osteosarcoma
Osteosarcoma - radiotherapy
Osteosarcoma - veterinary
Phenylalanine - analogs & derivatives
Phenylalanine - therapeutic use
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Summary:In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as clinical model of human melanoma and osteosarcoma. The study has been carried out on 33 dogs with oral cavity melanoma and 9 dogs with osteosarcoma. Dogs with spontaneous melanoma of oral cavity and osteosarcoma of extremities were selected by the results of clinical examination. Irradiation was carried out at the NCT facility of the IRT MEPhI reactor. Neutron irradiation without boron or gadolinium was chosen as a control method to evaluate the efficacy of NCT.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.03.067