Leptin as local inflammatory marker in COPD

• Published in: Respiratory medicine 2005, Vol.99 (1), p.70-74
• Main Authors: Broekhuizen, R., Vernooy, J.H.J., Schols, A.M.W.J., Dentener, M.A., Wouters, E.F.M.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anthropometry; Biological and medical sciences; Biomarkers - metabolism; C-Reactive Protein - metabolism; COPD; CRP; Cytokines; Forced Expiratory Volume; Humans; Immune system; Inflammation; Inflammation Mediators - metabolism; Leptin; Leptin - analysis; Leptin - metabolism; Lungs; Male; Medical sciences; Middle Aged; Pneumology; Proteins; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - physiopathology; Rodents; Sputum; Sputum - metabolism; Studies; TNF-α; Tumor Necrosis Factor-alpha - metabolism; Vital Capacity
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2004.03.029

Introduction: Chronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). Leptin is a pleiotropic cytokine thought to play a role in host response to inflammation. As recent studies have shown that leptin receptors are present in the lung, this study aimed to determine if leptin is detectable in induced sputum of COPD patients and if there is a relationship between leptin and other inflammatory markers in sputum. Methods: Sputum was induced in 14 male patients with moderate COPD (FEV 1: 56 (15) %pred.). Leptin, total tumour necrosis factor (TNF)- α, and C-reactive protein (CRP) were analyzed in induced sputum supernatant by ELISA. Leptin was also determined in EDTA plasma. Results: Leptin was detectable in induced sputum of 10 COPD patients. A significant relationship was found between sputum leptin and CRP ( r=0.943, P