Cells, scaffolds, and molecules for myocardial tissue engineering

Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology & therapeutics (Oxford) 2005-02, Vol.105 (2), p.151-163
Main Authors: Leor, Jonathan, Amsalem, Yoram, Cohen, Smadar
Format: Article
Language:English
Subjects:
Biocompatible Materials
Bioreactors
Cell Differentiation
Humans
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Myocardium - cytology
Neovascularization, Physiologic
Prostheses and Implants
Regeneration
Stem Cells - physiology
Tissue Engineering - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time, new approaches are conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration.
ISSN:0163-7258
DOI:10.1016/j.pharmthera.2004.10.003