Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction

Inflammation caused by activated macrophages and T lymphocytes may trigger plaque rapture in acute coronary syndrome (ACS). Anandamide and 2‐arachidonylglycerol (2‐AG) are macrophage‐derived signal lipids and may be involved in the pathogenesis of ACS, but no clinical relevant data have been reporte...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental & clinical pharmacology 2009-06, Vol.23 (3), p.351-357
Main Authors: Maeda, Naotaka, Osanai, Tomohiro, Kushibiki, Motoi, Fujiwara, Takayuki, Tamura, Yujin, Oowada, Shingen, Higuma, Takumi, Sasaki, Shingo, Yokoyama, Jin, Yoshimachi, Fuminobu, Matsunaga, Toshiro, Hanada, Hiroyuki, Okumura, Ken
Format: Article
Language:English
Subjects:
2-arachidonylglycerol
acute coronary syndrome
Aged
anandamide
Angina Pectoris - physiopathology
Angioplasty, Balloon, Coronary
Aorta - physiopathology
Arachidonic Acids - biosynthesis
Arachidonic Acids - blood
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Coronary Vessels - physiopathology
Endocannabinoids
Female
Glycerides - blood
Heart
Humans
inflammation
Inflammation - etiology
Inflammation - physiopathology
Male
Medical sciences
Middle Aged
Myocardial Infarction - physiopathology
Myocarditis. Cardiomyopathies
Pharmacology. Drug treatments
Polyunsaturated Alkamides - blood
Rupture, Spontaneous
stable effort angina
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inflammation caused by activated macrophages and T lymphocytes may trigger plaque rapture in acute coronary syndrome (ACS). Anandamide and 2‐arachidonylglycerol (2‐AG) are macrophage‐derived signal lipids and may be involved in the pathogenesis of ACS, but no clinical relevant data have been reported. In 43 acute myocardial infarction (AMI) patients (66 ± 2 years), blood samples were obtained from the aortic root and the infarct‐related coronary artery (IRA) using a PercuSurge system during primary percutaneous coronary intervention (PCI). In six patients with stable effort angina (SEA) (56 ± 6 years), blood samples were obtained from the site of stenosis during elective PCI. In 25 of the 43 AMI patients, anandamide was detected in the serum. Serum anandamide level was 35 ± 20 pmol/mL in the aorta and was significantly increased to 401 ± 134 pmol/mL in the IRA (P 
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2009.00679.x