Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis

Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis is shown to have a nonpolar cavity adjacent to the active site, allowing racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high apparent stereoselectivity.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2005-02, Vol.3 (3), p.401-403
Main Authors: Daniellou, Richard, Phenix, Christopher P, Tam, Pui Hang, Laliberte, Michael C, Palmer, David R J
Format: Article
Language:English
Subjects:
Bacillus subtilis - enzymology
Carbohydrate Conformation
Catalysis
Inositol - analogs & derivatives
Inositol - chemical synthesis
Inositol - chemistry
Kinetics
Oxidation-Reduction
Stereoisomerism
Sugar Alcohol Dehydrogenases - chemistry
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Description
Summary:Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis is shown to have a nonpolar cavity adjacent to the active site, allowing racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high apparent stereoselectivity.
ISSN:1477-0520
1477-0539
DOI:10.1039/b417757f