Culture results of heart valves resected because of streptococcal endocarditis: insights into duration of treatment to achieve valve sterilization

Objectives: To analyse the culture results of heart valves removed following streptococcal endocarditis in order to gain insight into the duration of treatment required for valve sterilization. Patients and methods: Retrospective review of 131 episodes of streptococcal endocarditis: 94 due to α-haem...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2005-02, Vol.55 (2), p.234-239
Main Authors: Upton, Arlo, Drinković, Dragana, Pottumarthy, Sudha, West, Teena, Morris, Arthur J.
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Endocarditis, Bacterial - drug therapy
Endocarditis, Bacterial - microbiology
Endocarditis, Bacterial - surgery
Female
Heart Valve Diseases - drug therapy
Heart Valve Diseases - microbiology
Heart Valve Diseases - surgery
Heart Valves - drug effects
Heart Valves - microbiology
Heart Valves - surgery
Humans
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Pharmacology. Drug treatments
Sterilization - methods
Streptococcus anginosus
Streptococcus anginosus - drug effects
Streptococcus anginosus - isolation & purification
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - isolation & purification
surgery
α-haemolytic streptococci
β-haemolytic streptococci
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Summary:Objectives: To analyse the culture results of heart valves removed following streptococcal endocarditis in order to gain insight into the duration of treatment required for valve sterilization. Patients and methods: Retrospective review of 131 episodes of streptococcal endocarditis: 94 due to α-haemolytic streptococci; 15 due to β-haemolytic streptococci; 10 due to nutritionally deficient streptococci; eight due to the Streptococcus anginosus group and four due to Streptococcus pneumoniae. Patients had their valves removed during antimicrobial treatment. Culture results were analysed with respect to duration of treatment before surgery. Results: For α-haemolytic streptococci, 17 (18%) valves were culture-positive and 77 (82%) culture-negative after a median (range) of 4 (1–20) and 16 (4–58) days of treatment, respectively, P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkh527