Recurrent aseptic meningitis associated with primary biliary cirrhosis

The etiological diagnosis of recurrent aseptic meningitis often requires difficult investigations. We report a case of recurrent aseptic meningitis associated with a primary biliary cirrhosis. A 37-year-old woman presented four recurrences of isolated meningitic syndrome with fever. Intravenous ster...

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Bibliographic Details
Published in:Revue neurologique 2005-01, Vol.161 (1), p.87-91
Main Authors: Bensa, C, Boscagli, A, Bourg, V, Bensaken, S, Chanalet, S, Lebrun, C
Format: Article
Language:eng ; fre
Subjects:
Adult
Autoantibodies
Autoimmune Diseases - complications
Autoimmune Diseases - pathology
Brain - pathology
Ear Canal - pathology
Ear, Inner - injuries
Ear, Inner - pathology
Female
Humans
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - pathology
Magnetic Resonance Imaging
Meningitis, Aseptic - etiology
Meningitis, Aseptic - pathology
Mitochondria - immunology
Recurrence
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Summary:The etiological diagnosis of recurrent aseptic meningitis often requires difficult investigations. We report a case of recurrent aseptic meningitis associated with a primary biliary cirrhosis. A 37-year-old woman presented four recurrences of isolated meningitic syndrome with fever. Intravenous steroid treatment was effective. Investigations revealed an old right tympano-labyrinthine fracture with, on MRI, an abnormal enhancement of the posterior wall of the internal auditory canal. Serum tests were also significantly positive for antimitochondria antibodies subtype M2. Definitive diagnosis was recurrent puriform aseptic meningitis secondary to an inflammatory non-septic ears-nose-throat focus in a latent autoimmune context of primary biliary cirrhosis. To our knowledge, this is the first case reported in literature.
ISSN:0035-3787
DOI:10.1016/S0035-3787(05)84979-3