Cut-off levels for breath carbon monoxide as a marker for cigarette smoking

ABSTRACT Aims  Current clinical studies often use a breath carbon monoxide (BCO) cut‐off level of 8 parts per million (p.p.m.) or higher to identify smoking. In this study, the cut‐off level of BCO as an indicator of smoking over the past 24 hours was re‐examined. Design  BCO and self‐reported smoki...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 2005-02, Vol.100 (2), p.159-167
Main Authors: Javors, Martin A., Hatch, John P., Lamb, Richard J.
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Biomarkers - analysis
Breath carbon monoxide
breath CO
Breath tests
Breath Tests - methods
Carbon monoxide
Carbon Monoxide - analysis
cigarette
cut-off
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Prognosis
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Sensitivity and Specificity
Smoking
Smoking Prevention
Tobacco, tobacco smoking
Toxicology
Truth Disclosure
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Summary:ABSTRACT Aims  Current clinical studies often use a breath carbon monoxide (BCO) cut‐off level of 8 parts per million (p.p.m.) or higher to identify smoking. In this study, the cut‐off level of BCO as an indicator of smoking over the past 24 hours was re‐examined. Design  BCO and self‐reported smoking were obtained each weekday for up to 14 weeks in 213 subjects paid to deliver reduced BCO values. Analysis of 12 386 paired values for reported smoking and BCO were analyzed. Findings  The 25% quartile, median and 75% quartile values for BCO were 1, 1 and 2 p.p.m. on non‐smoking days and 2, 5 and 12 p.p.m. on smoking days, respectively. Receiver‐operating characteristic (ROC) analysis indicated that BCO provided high diagnostic accuracy to distinguish between smoking and non‐smoking days [area under the curve (AUC) = 0.853, P 
ISSN:0965-2140
1360-0443
DOI:10.1111/j.1360-0443.2004.00957.x