Aurantosides G, H, and I:  Three New Tetramic Acid Glycosides from a Papua New Guinea Theonella swinhoei

Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, r...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-01, Vol.68 (1), p.104-107
Main Authors: RATNAYAKE, Anokha S., DAVIS, Rohan A., HARPER, Mary Kay, VELTRI, Charles A., ANDJELIC, Cynthia D., BARROWS, Louis R., IRELAND, Chris M.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
Lithistida
Marine
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Papua New Guinea
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Pyrrolidinones - chemistry
Pyrrolidinones - isolation & purification
Pyrrolidinones - pharmacology
Theonella swinhoei
Tumor Cells, Cultured
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Summary:Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, respectively. Aurantosides G-I (1-3) failed to show any significant cytotoxicity against the human colon tumor cell line HCT-116.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049721s