Human leukocyte antigen allele associations in type-1 autoimmune hepatitis patients from western India

Background and Aims:  The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type‐1 autoimmune hepatitis (AIH) among patients from western India. Methods:  In 20 patients and 120 healthy controls, polymera...

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Published in:Journal of gastroenterology and hepatology 2005-02, Vol.20 (2), p.193-197
Main Authors: SHANKARKUMAR, UMAPATHY, AMARAPURKAR, DEEPAK N, KANKONKAR, SHARADA
Format: Article
Language:English
Subjects:
Adult
Alleles
autoimmune hepatitis
Biological and medical sciences
Case-Control Studies
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Predisposition to Disease
Genotype
Hepatitis, Autoimmune - epidemiology
Hepatitis, Autoimmune - genetics
HLA Antigens - analysis
human leukocyte antigen associations
Humans
India - epidemiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
western India
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Summary:Background and Aims:  The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type‐1 autoimmune hepatitis (AIH) among patients from western India. Methods:  In 20 patients and 120 healthy controls, polymerase chain reaction amplified with sequence specific primers and hybridized with oligoprobes was carried out to elucidate the HLA A, B, C and DRB1 allele associations. Results:  The study revealed that A*0222 (20%vs 1.66%; P = 0.0001), A*3201 (15%vs 0.83%; P = 0.0004), A*680102 (30%vs 6.66%; P = 0.001), B*35 (40%vs 11.66%; P = 0.001), B*5501 (10%vs 0.83%; P = 0.008), Cw*0102 (15%vs 1.66%; P = 0.002) and Cw*070101 (50%vs 11.66%; P = 2.5E‐05) were significantly increased among the A, B and C alleles of AIH patients. Among the HLA DRB1 alleles, DRB1*0301 (20%vs 6.19%; P = 0.03), DRB1*1301 (15%vs 2.65%; P = 0.01), DRB1*14 (30%vs 11.5%; P = 0.02) and DRB1*1501 (40%vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls. Conclusions:  The present study indicates that the HLA susceptibility to type 1 AIH in the different populations studied is complex. © 2004 Blackwell Publishing Asia Pty Ltd
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2004.03608.x