A New Insight into Pathophysiological Mechanisms of Zinc in Diarrhea

An increasing amount of data showing the beneficial use of zinc (Zn) in treating diarrhea continues to emerge from epidemiological and clinical trials. However, without a thorough understanding of physiological mechanisms of Zn, it does not support policy recommendation to advocate the therapeutic u...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-05, Vol.1165 (1), p.279-284
Main Authors: Hoque, Kazi Mirajul, Sarker, Rafiquel, Guggino, Sandra E., Tse, Chung-Ming
Format: Article
Language:English
Subjects:
Antidiarrheals - therapeutic use
Caco-2 Cells
Cl secretion
Cyclic AMP - metabolism
diarrhea
Diarrhea - drug therapy
Diarrhea - etiology
Fluid Therapy
Humans
Intestinal Absorption
Intestines - metabolism
Na absorption
Sodium-Hydrogen Exchangers - metabolism
T84
zinc
Zinc - administration & dosage
Zinc - therapeutic use
Zinc Compounds - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An increasing amount of data showing the beneficial use of zinc (Zn) in treating diarrhea continues to emerge from epidemiological and clinical trials. However, without a thorough understanding of physiological mechanisms of Zn, it does not support policy recommendation to advocate the therapeutic use of Zn. Our data demonstrate that Zn is a potential antidiarrheal agent that provides substantial benefit by stimulating sodium absorption and inhibiting chloride secretion in intestinal epithelial cells. Thus, inclusion of Zn in oral rehydration solution (ORS) has the potential to markedly augment the effectiveness of ORS in the treatment of diarrhea.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1111/j.1749-6632.2009.04442.x