Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial

Summary Objective  To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. Design  Randomized controlled trial. Setting and participants  A total of 427 children with chronic suppurative otiti...

Full description

Saved in:
Bibliographic Details
Published in:Tropical medicine & international health 2005-02, Vol.10 (2), p.190-197
Main Authors: Macfadyen, Carolyn, Gamble, Carrol, Garner, Paul, Macharia, Isaac, Mackenzie, Ian, Mugwe, Peter, Oburra, Herbert, Otwombe, Kennedy, Taylor, Stephen, Williamson, Paula
Format: Article
Language:English
Subjects:
Adolescent
Alcohol
Anti-Infective Agents, Local - therapeutic use
Antibiotics
antiseptics
Biological and medical sciences
Boric Acids - therapeutic use
Child
Child, Preschool
Children & youth
Chronic Disease
Ciprofloxacin - therapeutic use
Developing Countries
Double-Blind Method
drug
Drug therapy
eardrops
Ears & hearing
Female
fluoroquinolones
Follow-Up Studies
General aspects
Hearing Disorders - etiology
hearing impairment
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
instillation
Kenya
Male
Medical sciences
otitis media
Otitis Media, Suppurative - complications
Otitis Media, Suppurative - drug therapy
randomized controlled trial
suppurative
Transdermal medication
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Objective  To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. Design  Randomized controlled trial. Setting and participants  A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841 schoolchildren in Kenya. Intervention  Topical ciprofloxacin (n = 216) or boric acid in alcohol (n = 211); child‐to‐child treatment twice daily for 2 weeks. Main outcome measures  Resolution of discharge (at 2 weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4 weeks. Results  At 2 weeks, discharge was resolved in 123 of 207 (59%) children given ciprofloxacin, and in 65 of 204 (32%) given boric acid (relative risk 1.86; 95% CI 1.48–2.35; P 
ISSN:1360-2276
1365-3156
DOI:10.1111/j.1365-3156.2004.01368.x