Effect of Probiotics on Intestinal Barrier Function

Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-05, Vol.1165 (1), p.183-189
Main Authors: Mennigen, Rudolf, Bruewer, Matthias
Format: Article
Language:English
Subjects:
Animals
bacterial translocation
Enteropathogenic Escherichia coli - pathogenicity
epithelial barrier
Humans
inflammatory bowel disease
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - therapy
intestinal barrier
Intestines - cytology
Intestines - immunology
Intestines - metabolism
Intestines - microbiology
probiotics
Probiotics - therapeutic use
tight junction
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Description
Summary:Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases by effectively improving intestinal barrier function. This article reviews available data on the effect of probiotics on intestinal barrier function in vitro, in animal models, and in clinical studies.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1111/j.1749-6632.2009.04059.x