Changing Fates on the Road to Neuronal Diversity

One of the longstanding goals of neurobiologists is to describe, in molecular terms, how a neural progenitor cell (NPC) can generate an ordered series of uniquely fated neurons and glia. Recent studies reveal that many, or all, neural-subtype identities can be linked to sequentially changing regulat...

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Bibliographic Details
Published in:Developmental cell 2005-02, Vol.8 (2), p.133-134
Main Author: Odenwald, Ward F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Drosophila
Drosophila - cytology
Drosophila - embryology
Drosophila - genetics
Fundamental and applied biological sciences. Psychology
Humans
Molecular and cellular biology
Mutation
Neuroglia - cytology
Neurons - cytology
Stem Cells - cytology
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Summary:One of the longstanding goals of neurobiologists is to describe, in molecular terms, how a neural progenitor cell (NPC) can generate an ordered series of uniquely fated neurons and glia. Recent studies reveal that many, or all, neural-subtype identities can be linked to sequentially changing regulatory programs within NPCs. Two new studies, in this issue of Developmental Cell, provide novel insights into the molecular details of how Drosophila NPCs transition from one offspring identity program to the next.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2005.01.005