Kawasaki disease: clinical behaviour and cardiovascular complications in children in a tertiary-care level hospital

To describe the clinical characteristics, outcome, and treatment response in a series of patients with Kawasaki disease (KD). Case-series, review of clinical records of children with KD diagnosis cared for from november 1999 to september 2006. 22 patients were included, male:female ratio, 1.4:1, 82%...

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Bibliographic Details
Published in:Archivos de cardiología de México 2009-01, Vol.79 (1), p.11-17
Main Authors: Gil Veloz, Mariana, Flores Ruiz, Eric M, Beirana Palencia, Luisa G, Miranda Novales, María Guadalupe, Huerta García, Gloria C, Solórzano Santos, Fortino
Format: Article
Language:Spanish
Subjects:
Adolescent
Cardiovascular Diseases - etiology
Child
Child, Preschool
Female
Hospitals
Humans
Infant
Male
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - diagnosis
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Summary:To describe the clinical characteristics, outcome, and treatment response in a series of patients with Kawasaki disease (KD). Case-series, review of clinical records of children with KD diagnosis cared for from november 1999 to september 2006. 22 patients were included, male:female ratio, 1.4:1, 82% younger than 5 years, 14% with atypical presentation. Of the 22 patients, 10 (45%) received intravenous gammaglobulin (IVGG) in the first 10 days of symptoms onset at the recommended dose; four of them had coronary artery damage but none developed residual aneurysmatic lesions. Eight received IVGG in a different dose or after 10 days, six of them had coronary lesions and in two the damage was permanent. Four patients did not receive IVGG, and two had residual aneurysmatic lesions. None of those who received adequate treatment developed coronary residual damage, in comparison with 33% who received inadequate or no treatment, but difference was not statistically significant (P =.06). KD is a rare clinical entity in our country; even though most of the cases occurred with classic clinical criteria, late referral and delay of treatment worsen the prognosis.
ISSN:1405-9940