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Relationship between exhaled nitric oxide and atopy in Asian young adults
Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults. Methodology: Subjects were assessed by: (i) the International Study of Asthma and Aller...
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| Published in: | Respirology (Carlton, Vic.) Vic.), 2005-01, Vol.10 (1), p.40-45 |
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| creator | CHNG, Seo Yi VAN BEVER, Hugo P LIAN, Derrick LEE, Shan Xian XU, Xin Ni WANG, Xiao Shan GOH, Daniel Yam Thiam |
| description | Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults.
Methodology: Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non‐rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FENO measurements performed online at a flow rate of 50 mL/s.
Results: Complete results were available for 84 subjects. FENO values were highest in atopic asthmatics (n = 34; median FENO, 59.8 p.p.b.; interquartile range, 30.4–85.5 p.p.b), followed by atopic nonasthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7–49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9–33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5–21.7 p.p.b). FENO values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3–75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7–23.8 p.p.b.; P |
| doi_str_mv | 10.1111/j.1440-1843.2005.00628.x |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67404588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67404588</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4058-1ed49381b6fdc1f51bf7ca3a67e25af8614db7343ac15be5035a265e30b4fcc3</originalsourceid><addsrcrecordid>eNqNkD1PwzAQhi0EolD4C8gTW4Id24k7MCAoBcSXSgUSi-U4F-qSJiVO1PTf49IKVm65k_w-59ODEKYkpL7OZiHlnARUchZGhIiQkDiSYbeDDn4fdv3MIhYkyWDQQ4fOzQghTBCxj3pUxAMaseQA3Y6h0I2tSje1C5xCswQoMXRTXUCGS9vU1uCqsxlgXWZYN9VihW2JL5zVJV5VbfmBddYWjTtCe7kuHBxvex9NroeTy5vg_ml0e3lxHxhOhAwoZHzAJE3jPDM0FzTNE6OZjhOIhM5lTHmWJowzbahIQfiTdRQLYCTluTGsj043axd19dWCa9TcOgNFoUuoWqfihBMupPRBuQmaunKuhlwtajvX9UpRotYW1UytZam1LLW2qH4sqs6jJ9s_2nQO2R-41eYD55vA0haw-vdiNR6-PPvJ88GGt66B7pfX9ae_nyVCvT2O1N2rvJo8vNypd_YN32aQZA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67404588</pqid></control><display><type>article</type><title>Relationship between exhaled nitric oxide and atopy in Asian young adults</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>CHNG, Seo Yi ; VAN BEVER, Hugo P ; LIAN, Derrick ; LEE, Shan Xian ; XU, Xin Ni ; WANG, Xiao Shan ; GOH, Daniel Yam Thiam</creator><creatorcontrib>CHNG, Seo Yi ; VAN BEVER, Hugo P ; LIAN, Derrick ; LEE, Shan Xian ; XU, Xin Ni ; WANG, Xiao Shan ; GOH, Daniel Yam Thiam</creatorcontrib><description>Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults.
Methodology: Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non‐rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FENO measurements performed online at a flow rate of 50 mL/s.
Results: Complete results were available for 84 subjects. FENO values were highest in atopic asthmatics (n = 34; median FENO, 59.8 p.p.b.; interquartile range, 30.4–85.5 p.p.b), followed by atopic nonasthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7–49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9–33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5–21.7 p.p.b). FENO values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3–75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7–23.8 p.p.b.; P < 0.0001), regardless of asthma and rhinitis status. FENO levels correlated with the severity of atopy (wheal size) for both asthmatic (r = 0.44, P = 0.005) and nonasthmatic subjects (r = 0.48, P = 0.001). There was no significant difference in FENO levels between nonatopic asthmatics and nonatopic nonasthmatic subjects (P = 0.25).
Conclusions: Increased FENO levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/j.1440-1843.2005.00628.x</identifier><identifier>PMID: 15691237</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adolescent ; Adult ; Allergens ; Asian ; asthma ; Asthma - metabolism ; atopy ; Exhalation - physiology ; Female ; Humans ; Hypersensitivity, Immediate - metabolism ; Intradermal Tests ; Male ; nitric oxide ; Nitric Oxide - analysis ; rhinitis ; Rhinitis, Allergic, Perennial - metabolism ; Rhinitis, Allergic, Seasonal - metabolism ; Singapore ; Spirometry - methods</subject><ispartof>Respirology (Carlton, Vic.), 2005-01, Vol.10 (1), p.40-45</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4058-1ed49381b6fdc1f51bf7ca3a67e25af8614db7343ac15be5035a265e30b4fcc3</citedby><cites>FETCH-LOGICAL-c4058-1ed49381b6fdc1f51bf7ca3a67e25af8614db7343ac15be5035a265e30b4fcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15691237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHNG, Seo Yi</creatorcontrib><creatorcontrib>VAN BEVER, Hugo P</creatorcontrib><creatorcontrib>LIAN, Derrick</creatorcontrib><creatorcontrib>LEE, Shan Xian</creatorcontrib><creatorcontrib>XU, Xin Ni</creatorcontrib><creatorcontrib>WANG, Xiao Shan</creatorcontrib><creatorcontrib>GOH, Daniel Yam Thiam</creatorcontrib><title>Relationship between exhaled nitric oxide and atopy in Asian young adults</title><title>Respirology (Carlton, Vic.)</title><addtitle>Respirology</addtitle><description>Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults.
Methodology: Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non‐rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FENO measurements performed online at a flow rate of 50 mL/s.
Results: Complete results were available for 84 subjects. FENO values were highest in atopic asthmatics (n = 34; median FENO, 59.8 p.p.b.; interquartile range, 30.4–85.5 p.p.b), followed by atopic nonasthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7–49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9–33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5–21.7 p.p.b). FENO values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3–75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7–23.8 p.p.b.; P < 0.0001), regardless of asthma and rhinitis status. FENO levels correlated with the severity of atopy (wheal size) for both asthmatic (r = 0.44, P = 0.005) and nonasthmatic subjects (r = 0.48, P = 0.001). There was no significant difference in FENO levels between nonatopic asthmatics and nonatopic nonasthmatic subjects (P = 0.25).
Conclusions: Increased FENO levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergens</subject><subject>Asian</subject><subject>asthma</subject><subject>Asthma - metabolism</subject><subject>atopy</subject><subject>Exhalation - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - metabolism</subject><subject>Intradermal Tests</subject><subject>Male</subject><subject>nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>rhinitis</subject><subject>Rhinitis, Allergic, Perennial - metabolism</subject><subject>Rhinitis, Allergic, Seasonal - metabolism</subject><subject>Singapore</subject><subject>Spirometry - methods</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkD1PwzAQhi0EolD4C8gTW4Id24k7MCAoBcSXSgUSi-U4F-qSJiVO1PTf49IKVm65k_w-59ODEKYkpL7OZiHlnARUchZGhIiQkDiSYbeDDn4fdv3MIhYkyWDQQ4fOzQghTBCxj3pUxAMaseQA3Y6h0I2tSje1C5xCswQoMXRTXUCGS9vU1uCqsxlgXWZYN9VihW2JL5zVJV5VbfmBddYWjTtCe7kuHBxvex9NroeTy5vg_ml0e3lxHxhOhAwoZHzAJE3jPDM0FzTNE6OZjhOIhM5lTHmWJowzbahIQfiTdRQLYCTluTGsj043axd19dWCa9TcOgNFoUuoWqfihBMupPRBuQmaunKuhlwtajvX9UpRotYW1UytZam1LLW2qH4sqs6jJ9s_2nQO2R-41eYD55vA0haw-vdiNR6-PPvJ88GGt66B7pfX9ae_nyVCvT2O1N2rvJo8vNypd_YN32aQZA</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>CHNG, Seo Yi</creator><creator>VAN BEVER, Hugo P</creator><creator>LIAN, Derrick</creator><creator>LEE, Shan Xian</creator><creator>XU, Xin Ni</creator><creator>WANG, Xiao Shan</creator><creator>GOH, Daniel Yam Thiam</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Relationship between exhaled nitric oxide and atopy in Asian young adults</title><author>CHNG, Seo Yi ; VAN BEVER, Hugo P ; LIAN, Derrick ; LEE, Shan Xian ; XU, Xin Ni ; WANG, Xiao Shan ; GOH, Daniel Yam Thiam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4058-1ed49381b6fdc1f51bf7ca3a67e25af8614db7343ac15be5035a265e30b4fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergens</topic><topic>Asian</topic><topic>asthma</topic><topic>Asthma - metabolism</topic><topic>atopy</topic><topic>Exhalation - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - metabolism</topic><topic>Intradermal Tests</topic><topic>Male</topic><topic>nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>rhinitis</topic><topic>Rhinitis, Allergic, Perennial - metabolism</topic><topic>Rhinitis, Allergic, Seasonal - metabolism</topic><topic>Singapore</topic><topic>Spirometry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHNG, Seo Yi</creatorcontrib><creatorcontrib>VAN BEVER, Hugo P</creatorcontrib><creatorcontrib>LIAN, Derrick</creatorcontrib><creatorcontrib>LEE, Shan Xian</creatorcontrib><creatorcontrib>XU, Xin Ni</creatorcontrib><creatorcontrib>WANG, Xiao Shan</creatorcontrib><creatorcontrib>GOH, Daniel Yam Thiam</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHNG, Seo Yi</au><au>VAN BEVER, Hugo P</au><au>LIAN, Derrick</au><au>LEE, Shan Xian</au><au>XU, Xin Ni</au><au>WANG, Xiao Shan</au><au>GOH, Daniel Yam Thiam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between exhaled nitric oxide and atopy in Asian young adults</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><addtitle>Respirology</addtitle><date>2005-01</date><risdate>2005</risdate><volume>10</volume><issue>1</issue><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults.
Methodology: Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non‐rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FENO measurements performed online at a flow rate of 50 mL/s.
Results: Complete results were available for 84 subjects. FENO values were highest in atopic asthmatics (n = 34; median FENO, 59.8 p.p.b.; interquartile range, 30.4–85.5 p.p.b), followed by atopic nonasthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7–49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9–33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5–21.7 p.p.b). FENO values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3–75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7–23.8 p.p.b.; P < 0.0001), regardless of asthma and rhinitis status. FENO levels correlated with the severity of atopy (wheal size) for both asthmatic (r = 0.44, P = 0.005) and nonasthmatic subjects (r = 0.48, P = 0.001). There was no significant difference in FENO levels between nonatopic asthmatics and nonatopic nonasthmatic subjects (P = 0.25).
Conclusions: Increased FENO levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15691237</pmid><doi>10.1111/j.1440-1843.2005.00628.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Allergens Asian asthma Asthma - metabolism atopy Exhalation - physiology Female Humans Hypersensitivity, Immediate - metabolism Intradermal Tests Male nitric oxide Nitric Oxide - analysis rhinitis Rhinitis, Allergic, Perennial - metabolism Rhinitis, Allergic, Seasonal - metabolism Singapore Spirometry - methods |
| title | Relationship between exhaled nitric oxide and atopy in Asian young adults |
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