A facile three-component solid phase synthesis of steroidal A-ring fused pyrimidines under microwave irradiation

The preparation of ring-A fused pyrimidines at the steroidal 2,3-position is herein described. The novel steroidal pyrimidines were prepared from the solid phase three-component reaction of 2-hydroxymethylene-3-keto steroids, arylaldehydes and ammonium acetate under microwave irradiation.

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Bibliographic Details
Published in:Steroids 2009-09, Vol.74 (9), p.730-734
Main Authors: Barthakur, Madan G., Gogoi, Shyamalee, Dutta, Mandakini, Boruah, Romesh C.
Format: Article
Language:English
Subjects:
Acetates - chemistry
Aldehydes - chemistry
Ammonium acetate
Arylaldehyde
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Heterosteroids
Ketosteroids - chemistry
Microwave
Microwaves
Pyrimidine
Pyrimidines - chemistry
Steroids - chemical synthesis
Steroids - chemistry
Vertebrates: endocrinology
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Description
Summary:The preparation of ring-A fused pyrimidines at the steroidal 2,3-position is herein described. The novel steroidal pyrimidines were prepared from the solid phase three-component reaction of 2-hydroxymethylene-3-keto steroids, arylaldehydes and ammonium acetate under microwave irradiation.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2009.03.006