Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma

We have examined the association of the CCND1 A/G 870 polymorphism with susceptibility and outcome in 174 German patients with oral SCC (OSCC). The CCND1 G 870 allele frequency was increased in cases (G 870 = 0.65) when compared to controls ( n = 155, G 870 = 0.54) and the distribution of CCND1 geno...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology 2005-02, Vol.41 (2), p.156-160
Main Authors: Holley, Sarah L., Matthias, Christoph, Jahnke, Volker, Fryer, Anthony A., Strange, Richard C., Hoban, Paul R.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - genetics
Cyclin D1
Cyclin D1 - genetics
Female
Genetic polymorphism
Genetic Predisposition to Disease
Genetic susceptibility
Humans
Logistic Models
Male
Medical sciences
Middle Aged
Mouth Neoplasms - genetics
Oral cancer
Otorhinolaryngology. Stomatology
Polymorphism, Genetic
Risk Factors
Smoking - adverse effects
Smoking - genetics
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have examined the association of the CCND1 A/G 870 polymorphism with susceptibility and outcome in 174 German patients with oral SCC (OSCC). The CCND1 G 870 allele frequency was increased in cases (G 870 = 0.65) when compared to controls ( n = 155, G 870 = 0.54) and the distribution of CCND1 genotypes were significantly different ( p = 0.014). Using logistic regression, correcting for age, gender and tobacco consumption, an increased frequency of the CCND1 GG 870 genotype was observed in the OSCC cases ( p = 0.025, OR 3.37, 95% CI 1.61–9.80). No significant associations were observed between CCND1 A/G 870 and tumour histological factors. Our data suggests that the CCND1 GG 870 genotype is associated with increased susceptibility to OSCC. The involvement of cyclin D1 polymorphism in mechanisms of SCC development may differ in the different sub-sites of the head and neck.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2004.08.005