Male–female differences in the risk of tuberculosis in dialysis patients

Aim To define any gender-related differences in the prevalence and risk for tuberculosis (TB) in hemodialysis (HD) patients. Methods All active TB cases were recorded during a 36-month follow-up of 272 (193 male and 79 female) HD patients. Entering the study, HD patients were tested with tuberculin...

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Bibliographic Details
Published in:International urology and nephrology 2009, Vol.41 (3), p.671-677
Main Authors: Christopoulos, A. I., Diamantopoulos, A. A., Dimopoulos, P. A., Goumenos, D. S., Barbalias, G. A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Medicine
Medicine & Public Health
Middle Aged
Mycobacterium
Nephrology
Nephrology - Original Paper
Prevalence
Prospective Studies
Renal Dialysis
Risk Factors
Sex Distribution
Sex Factors
Tuberculosis - complications
Tuberculosis - epidemiology
Urology
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Summary:Aim To define any gender-related differences in the prevalence and risk for tuberculosis (TB) in hemodialysis (HD) patients. Methods All active TB cases were recorded during a 36-month follow-up of 272 (193 male and 79 female) HD patients. Entering the study, HD patients were tested with tuberculin and 2,4-dinitrochlorobenzene, and a cell-mediated immunity (CMI) index was estimated. Relative risks (RR) for TB were calculated considering subjects from the background general population as a reference group. The independent effect of age, BMI and tuberculin sensitivity was determined using Cox’s proportional hazard model. Results Female HD patients presented significantly lower CMI indices and rates of positive Mantoux tests, but higher rates of DM, as compared to males. The male:female ratio in TB for the general and HD patients population was 1.8 and 0.6, respectively. There was a significantly lower TB prevalence in male as compared to female HD patients (7.7% vs. 11.3%), and a subsequent female predominance in risk for TB in those HD patients aged
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-008-9479-8