Quantitative risk stratification and individual comprehensive therapy for invasive bladder cancers in China

Background To evaluate the risk factors for invasive bladder cancer and to develop a predictive model for the improvement of individual comprehensive therapy for invasive bladder cancers. Materials and methods The records of 356 patients with invasive bladder cancer, operated on at three Chinese med...

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Bibliographic Details
Published in:International urology and nephrology 2009, Vol.41 (3), p.571-577
Main Authors: Niu, Haitao, Shao, Shixiu, Zhang, Zongliang, Wu, Shuai, Cheng, Bo, Pang, Dequan, E, Yajun, Dong, Shengguo, Sun, Guang, Chang, Jiwu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
China
Cystectomy
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Nephrology
Risk Assessment
Survival Rate
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - therapy
Urology
Urology - Original Paper
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Summary:Background To evaluate the risk factors for invasive bladder cancer and to develop a predictive model for the improvement of individual comprehensive therapy for invasive bladder cancers. Materials and methods The records of 356 patients with invasive bladder cancer, operated on at three Chinese medical institutes, were reviewed. The Cox proportional hazards regression model was used to assess the clinical and pathological variables affecting disease-free survival (DFS). The regression coefficients determined by Cox regression analysis were used to construct a predictive index (PI). PI was used to categorize the patients into different risk groups. Kaplan–Meier survival curves followed with log-rank test were plotted to compare the difference. Results Tumor configuration (RR = 1.60, P  = 0.01), multiplicity (RR = 1.41, P  = 0.04), histological subtype (RR = 2.13, P  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-008-9470-4