Dynamics of the self-assembly of unilamellar vesicles

We have studied the transient stages in the formation of unilamellar vesicles with millisecond time resolution. The self-assembly was initiated by rapid mixing of equimolar amounts of anionic and zwitterionic micelles and the transient micellar entities were probed by time-resolved small-angle x-ray...

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Bibliographic Details
Published in:Physical review letters 2005-01, Vol.94 (3), p.038303.1-038303.4, Article 038303
Main Authors: WEISS, T. M, NARAYANAN, T, WOLF, C, GRADZIELSKI, M, PANINE, P, FINET, S, HELSBY, W. I
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Crystallization - methods
Exact sciences and technology
General and physical chemistry
General, apparatus, technics of preparation
Kinetics
Lipid Bilayers - chemistry
Liposomes - chemistry
Macromolecular Substances - chemistry
Membrane Fluidity
Models, Chemical
Models, Molecular
Molecular Conformation
Particle Size
Solutions
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Summary:We have studied the transient stages in the formation of unilamellar vesicles with millisecond time resolution. The self-assembly was initiated by rapid mixing of equimolar amounts of anionic and zwitterionic micelles and the transient micellar entities were probed by time-resolved small-angle x-ray scattering. Within the mixing time, original micelles transformed to disklike micelles which evolved further to a critical size and then closed to form monodisperse unilamellar vesicles within a second. Subsequent growth led to an unexpected broadening of the vesicle size distribution.
ISSN:0031-9007
1079-7114
DOI:10.1103/physrevlett.94.038303