Maternal and Infant Characteristics Associated With Perinatal Arterial Stroke in the Infant

CONTEXT Perinatal arterial ischemic stroke (PAS) is a common cause of hemiplegic cerebral palsy. Risk factors for this condition have not been clearly defined. OBJECTIVE To determine maternal and infant characteristics associated with PAS. DESIGN, SETTING, AND PATIENTS Case-control study nested with...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2005-02, Vol.293 (6), p.723-729
Main Authors: Lee, Janet, Croen, Lisa A, Backstrand, Kendall H, Yoshida, Cathleen K, Henning, Louis H, Lindan, Camilla, Ferriero, Donna M, Fullerton, Heather J, Barkovich, A. J, Wu, Yvonne W
Format: Article
Language:English
Subjects:
Babies
Biological and medical sciences
Blood vessels
Brain - diagnostic imaging
Brain - pathology
Case-Control Studies
Female
Fetal Diseases - epidemiology
Fetal Diseases - etiology
General aspects
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - etiology
Magnetic Resonance Imaging
Medical sciences
Mothers
Multivariate Analysis
Neurology
Placenta - pathology
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - physiopathology
Risk Factors
Stroke
Stroke - diagnosis
Stroke - epidemiology
Stroke - etiology
Tomography, X-Ray Computed
Vascular diseases and vascular malformations of the nervous system
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Summary:CONTEXT Perinatal arterial ischemic stroke (PAS) is a common cause of hemiplegic cerebral palsy. Risk factors for this condition have not been clearly defined. OBJECTIVE To determine maternal and infant characteristics associated with PAS. DESIGN, SETTING, AND PATIENTS Case-control study nested within the cohort of all 199 176 infants born from 1997 through 2002 in the Kaiser Permanente Medical Care Program, a managed care organization providing care for more than 3 million residents of northern California. Case patients were confirmed by review of brain imaging and medical records (n = 40). Three controls per case were randomly selected from the study population. MAIN OUTCOME MEASURE Association of maternal and infant complications with risk of PAS. RESULTS The population prevalence of PAS was 20 per 100 000 live births. The majority (85%) of infants with PAS were delivered at term. The following prepartum and intrapartum factors were more common among case than control infants: primiparity (73% vs 44%, P = .002), fetal heart rate abnormality (46% vs 14%, P
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.293.6.723