Panel-Reactive Screening and Treatment Practices Following Bridge to Transplantation Ventricular Assist Device Placement

Abstract The use of left ventricular assist devices (LVAD) as a bridge to transplantation is associated with the development of circulating antibodies. We conducted a survey of all adult cardiac transplantation programs in the United States in an attempt to define current practices with regard to LV...

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Bibliographic Details
Published in:Transplantation proceedings 2009-06, Vol.41 (5), p.1813-1815
Main Authors: Freudenberger, R.S, Tawfik, I, Shinnar, M, Pendergast, T
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - prevention & control
Graft Survival
Heart Transplantation - immunology
Heart Transplantation - physiology
Heart Ventricles
Heart-Assist Devices
Histocompatibility Testing
Humans
Lung Transplantation - immunology
Lung Transplantation - physiology
Medical sciences
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surveys and Questionnaires
Tissue, organ and graft immunology
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Summary:Abstract The use of left ventricular assist devices (LVAD) as a bridge to transplantation is associated with the development of circulating antibodies. We conducted a survey of all adult cardiac transplantation programs in the United States in an attempt to define current practices with regard to LVAD implantation, monitoring panel-reactive antibody (PRA) levels, treatment options, and peritransplantation management. Pretransplantation sensitization with the use of LVAD is a concern to the majority of transplantation professionals and there is no consensus on the need or mode of treatment.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.03.062