The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome

• Published in: Archives of gynecology and obstetrics 2009-08, Vol.280 (2), p.263-269
• Main Authors: Ozcimen, Emel Ebru, Uckuyu, Ayla, Ciftci, Faika Ceylan, Zeyneloglu, Hulusi Bulent
• Format: Article
• Language: English
• Subjects: Adult; Antidiabetics; Endocrinology; Female; Gynecology; Human Genetics; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Medicine; Medicine & Public Health; Metformin - pharmacology; Metformin - therapeutic use; Obstetrics/Perinatology/Midwifery; Original Article; Ovary - blood supply; Ovary - diagnostic imaging; Polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; Prospective Studies; Regional Blood Flow - drug effects; Ultrasonography, Doppler, Color; Young Adult
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-008-0904-0

Objective To evaluate the effects of metformin on the ovarian stromal blood perfusion in the patients with polycystic ovary syndrome (PCOS). Methods Twenty-five women with PCOS who underwent a Doppler examination of the ovarian stroma was evaluated; hormonal, anthropometric, and biochemical parameters of patients were determined. After the patients were treated with 850 mg metformin twice a day for 6 months, the same parameters were evaluated in the same patients. Results After metformin treatment, although pulsatility index (PI) was increased from 1.80 ± 1.23, 1.84 ± 1.28 to 2.20 ± 1.10, 2.19 ± 0.83 in the right and left ovary, respectively, and resistance index was increased from 0.84 ± 0.25, 0.83 ± 0.23 to 1.16 ± 0.37, 1.10 ± 0.26 in the right and left ovary respectively ( P