Production of [17F]CH3F (t1/2=65 s), an improved PET tracer for rCBF measurement

Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline...

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Bibliographic Details
Published in:Applied radiation and isotopes 2005-04, Vol.62 (4), p.525-532
Main Authors: Barnhart, T E, Converse, A K, Dabbs, K A, Schueller, M J, Stone, C K, Nickles, R J, Roberts, A D
Format: Article
Language:English
Subjects:
Cerebrovascular Circulation
Fluorine Radioisotopes - chemistry
Humans
Hydrocarbons, Fluorinated - chemical synthesis
Isotope Labeling - methods
Positron-Emission Tomography - methods
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Summary:Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.
ISSN:0969-8043
DOI:10.1016/j.apradiso.2004.08.044