Microvesicles: Messengers and mediators of tumor progression

Cellular interactions play a crucial role in progression, angiogenesis and invasiveness of tumors, including glioma. The traditionally accepted view is that medium and long-range cellular communications occur primarily through gradients of soluble ligands, recognizable by the cell-associated recepto...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2009-07, Vol.8 (13), p.2014-2018
Main Authors: Al-Nedawi, Khalid, Meehan, Brian, Rak, Janusz
Format: Article
Language:English
Subjects:
Binding
Biology
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Bioscience
Brain Neoplasms - etiology
Calcium
Cancer
Cell
Cell Communication
Cell-Derived Microparticles - metabolism
Cycle
Disease Progression
Exosomes
Glioma - etiology
Humans
Landes
Neovascularization, Pathologic
Oncogenes
Organogenesis
Proteins
Receptor, Epidermal Growth Factor - genetics
Receptor, Epidermal Growth Factor - metabolism
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Summary:Cellular interactions play a crucial role in progression, angiogenesis and invasiveness of tumors, including glioma. The traditionally accepted view is that medium and long-range cellular communications occur primarily through gradients of soluble ligands, recognizable by the cell-associated receptors. Recent findings, however, suggest the existence of another mode of intercellular communication, where the 'units' of information are microvesicles containing a multitude of biologically active protein and RNA species, including oncogenic receptors, such as EGFRvIII. Moreover, microvesicles can be retrieved from the circulating blood of cancer patients, and reveal the presence of oncogenes in their tumors, thereby potentially serving as information-rich prognostic and predictive biomarkers.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.8.13.8988