Sustained NPY Overexpression in the PVN Results in Obesity via Temporarily Increasing Food Intake

Increasing neuropeptide Y (NPY) signaling in the paraventricular nucleus (PVN) by recombinant adeno‐associated virus (rAAV)‐mediated overexpression of NPY in rats, results in hyperphagia and obesity in rats. To determine the importance of hyperphagia in the observed obesity phenotype, we pair‐fed a...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2009-07, Vol.17 (7), p.1448-1450
Main Authors: Tiesjema, Birgitte, La Fleur, Susanne E, Luijendijk, Mieneke C.M, Adan, Roger A.H
Format: Article
Language:English
Subjects:
Adenoviridae
animal models
Animals
Body temperature
Body Temperature - physiology
Body Weight - physiology
Disease Models, Animal
Eating - drug effects
Eating - physiology
Food
food intake
Hyperphagia - complications
Hyperphagia - metabolism
Hyperphagia - physiopathology
hypothalamic regulation
Hypothalamus
Injections
Male
neuropeptide Y
Neuropeptide Y - administration & dosage
Neuropeptide Y - metabolism
Neuropeptide Y - pharmacology
Neuropeptides
Neurosciences
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
overeating
Paraventricular Hypothalamic Nucleus - metabolism
paraventricular nucleus
Physiology
Rats
Rats, Wistar
signal transduction
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Summary:Increasing neuropeptide Y (NPY) signaling in the paraventricular nucleus (PVN) by recombinant adeno‐associated virus (rAAV)‐mediated overexpression of NPY in rats, results in hyperphagia and obesity in rats. To determine the importance of hyperphagia in the observed obesity phenotype, we pair‐fed a group of AAV‐NPY‐injected rats to AAV‐control‐injected rats and compared parameters of energy balance to ad libitum fed AAV‐NPY‐injected rats. For 3 weeks, AAV‐NPY‐injected rats, received the same amount of food as ad libitum‐fed rats injected with control rAAV They did not gain more body weight than these controls. When allowed access to food ad libitum, these AAV‐NPY‐injected rats increased food intake, which subsequently decreased when rats reached the same body weight as AAV‐NPY‐injected rats that were fed ad libitum for the entire study. These data indicate that overexpression of NPY in the PVN results in obesity by increasing food intake until a certain body weight is achieved.
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2008.670