Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes

Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided...

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Bibliographic Details
Published in:British journal of nutrition 2005-01, Vol.93 (1), p.11-13
Main Authors: Linko, Anna-Maria, Adlercreutz, Herman
Format: Article
Language:English
Subjects:
Alkylresorcinols
Barley
Biological and medical sciences
Biomarkers
Blood
blood serum
Bread
Bread - analysis
Diet
Dietary Fiber - metabolism
Erythrocyte Membrane - metabolism
Erythrocyte membranes
Erythrocytes
Feeding. Feeding behavior
food intake
Fundamental and applied biological sciences. Psychology
Gluten
Grain
Humans
Lipids
Membranes
nutrient uptake
Nutrition research
Phenols
Plasma
Resorcinols - blood
Resorcinols - pharmacokinetics
reticulocytes
rye
Secale - metabolism
Triticum - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
volunteers
Wheat
Whole grain
whole grain foods
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Summary:Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks 1 and 2. Erythrocyte membrane AR concentrations increased an average of 231 nmol/l of packed erythrocytes (P=0·036) after consumption of whole-grain rye and wheat products. Plasma AR levels increased an average of 175 nmol/l (P=0·058) When intake of whole-grain products was constant, erythrocyte membrane and plasma AR levels remained stable. Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN20041281