Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells

Several molecules that suppress metastasis without suppressing tumorigenicity have been identified, but their mechanisms of action have not yet been determined. Many block growth at the secondary site, suggesting involvement in how cells respond to signals from the extracellular milieu. Breast cance...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2005-02, Vol.65 (3), p.713-717
Main Authors: DEWALD, Daryll B, TORABINEJAD, Javad, SAMANT, Rajeev S, JOHNSTON, Derrick, ERIN, Nuray, SHOPE, Joseph C, YI XIE, WELCH, Danny R
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Line, Tumor
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Neoplasm Metastasis
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasm Proteins - physiology
Pharmacology. Drug treatments
Phosphatidylinositols - metabolism
Phosphatidylinositols - physiology
Repressor Proteins
Signal Transduction - physiology
Transfection
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several molecules that suppress metastasis without suppressing tumorigenicity have been identified, but their mechanisms of action have not yet been determined. Many block growth at the secondary site, suggesting involvement in how cells respond to signals from the extracellular milieu. Breast cancer metastasis suppressor 1 (BRMS1)-transfected MDA-MB-435 cells were examined for modifications of phosphoinositide signaling as a potential mechanism for metastasis suppression. 435/BRMS1 cells expressed
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.713.65.3