The role of serum CA-125 levels in early-stage epithelial ovarian cancer on preoperative CT and MRI

• Published in: European journal of surgical oncology 2009-08, Vol.35 (8), p.870-876
• Main Authors: Kim, H.S, Kim, J.W, Cho, J.Y, Chung, H.H, Park, N.H, Song, Y.S, Kim, S.H, Kang, S.B
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - blood; Adenocarcinoma - diagnosis; Adenocarcinoma - pathology; Adult; Advanced-stage disease; Aged; Antineoplastic Agents - administration & dosage; CA-125 Antigen - blood; Early-stage epithelial ovarian cancer; Female; Hematology, Oncology and Palliative Medicine; Humans; Magnetic Resonance Imaging; Middle Aged; MRI; Neoplasm Staging; Ovarian Neoplasms - blood; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - pathology; Predictive Value of Tests; Prognosis; Retrospective Studies; Serum CA-125 level; Surgery; Survival Analysis; Tomography, X-Ray Computed
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2009.01.005

Abstract Background We sought to identify the role of serum CA-125 levels in early-stage epithelial ovarian cancer (EOC) on preoperative CT and MRI. Methods Clinical data of 101 patients with early-stage EOC on preoperative CT and MRI were collected between January 2000 and December 2007. Clinical stage I ( n = 59) was defined as tumor limited to the ovaries with or without ascites, whereas clinical stage II ( n = 42) was defined as tumor within the pelvis with or without ascites. The primary endpoint was to investigate the efficacy of serum CA-125 levels for the prediction of advanced-stage disease, and secondary endpoints were to evaluate the accuracy of preoperative CT and MRI, and to examine the role of serum CA-125 levels as a prognostic factor for survival. Results The results of preoperative CT and MRI were concordant with no peritoneal implants outside the pelvis in 50/101 (50%) and no lymph node metastasis in 71/101 (70%) patients. The receiver operating characteristic curves showed that best cut-off values of serum CA-125 levels were 320 U/ml (71% sensitivity, 84% specificity) and 510 U/ml (67% sensitivity, 80% specificity) for the prediction of peritoneal implants outside the pelvis and lymph node metastasis. The serum CA-125 level (≥320 U/ml) was a significant factor for the prediction of advanced-stage disease (adjusted OR, 7.43; 95% CI, 2.39–23.04). However, it was not an independent prognostic factor for survival. Conclusions Serum CA-125 levels may be very useful for the prediction of advanced-stage disease in early-stage EOC on preoperative CT and MRI.