Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B

• Published in: Digestive diseases and sciences 2009-08, Vol.54 (8), p.1758-1763
• Main Authors: Kim, Do Young, Kim, Seung Up, Ahn, Sang Hoon, Park, Jun Yong, Lee, Jung Min, Park, Young Nyun, Yoon, Ki Tae, Paik, Yong Han, Lee, Kwan Sik, Chon, Chae Yoon, Han, Kwang-Hyub
• Format: Article
• Language: English
• Subjects: Adult; Biochemistry; Biological and medical sciences; Biopsy; Diagnosis, Differential; Elasticity Imaging Techniques - methods; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis B, Chronic - diagnostic imaging; Hepatology; Human viral diseases; Humans; Infectious diseases; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - diagnostic imaging; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Other diseases. Semiology; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Transplant Surgery; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Viral diseases; Viral hepatitis
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-008-0541-2

Background It is difficult to differentiate early compensated cirrhosis from chronic hepatitis solely by clinical features. The aim of this study was to assess the usefulness of liver stiffness measurement (LSM) for detection of early compensated liver cirrhosis in chronic hepatitis B (CHB). Methods Ninety-one consecutive CHB patients who underwent liver biopsy (LB) and LSM were recruited. All patients did not fulfill the clinical criteria for cirrhosis. The cutoff of LSM for cirrhosis was 10.3 kPa. Results All patients were divided into either group A (cirrhosis) or group B (CHB) according to LB result. The median LSM values of groups A and B were 11.8 and 7.6 kPa, respectively (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of LSM in predicting cirrhosis were 0.59, 0.78, 0.68, and 0.72, respectively. The area under the receiver operating characteristics curve (AUROC) of LSM was 0.803, whereas the AUROCs of aspartate to alanine aminotransferase ratio (AAR) and aspartate aminotransferase to platelet ratio index (APRI) were 0.488 and 0.723, respectively. Conclusions LSM showed an acceptable diagnostic accuracy for detecting early compensated cirrhosis in CHB.