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Protonation equilibrium and lipophilicity of moxifloxacin
This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient vers...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2005-02, Vol.37 (2), p.389-393 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c450t-bf3b5593da6e805f4773fc60ae7f10aeddb4933168c8e37216e383a2b2a83cc13 |
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| cites | cdi_FETCH-LOGICAL-c450t-bf3b5593da6e805f4773fc60ae7f10aeddb4933168c8e37216e383a2b2a83cc13 |
| container_end_page | 393 |
| container_issue | 2 |
| container_start_page | 389 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 37 |
| creator | Langlois, Marie-Hélène Montagut, Martine Dubost, Jean-Pierre Grellet, Jean Saux, Marie-Claude |
| description | This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in
n-octanol/buffer system which reached near
pI. The true partition coefficient was calculated from the log
P
app and microconstants values. |
| doi_str_mv | 10.1016/j.jpba.2004.10.022 |
| format | article |
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n-octanol/buffer system which reached near
pI. The true partition coefficient was calculated from the log
P
app and microconstants values.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2004.10.022</identifier><identifier>PMID: 15708683</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>1-Octanol ; Analysis ; Analytical, structural and metabolic biochemistry ; Aza Compounds - chemistry ; Biological and medical sciences ; Buffers ; Fluoroquinolones ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Hydrogen-Ion Concentration ; Lipids - chemistry ; Macroconstants ; Medical sciences ; Microconstants ; Models, Chemical ; Moxifloxacin ; Octanol/buffer partition coefficients ; Pharmacology. Drug treatments ; Protons ; Quinolines - chemistry ; Solutions ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2005-02, Vol.37 (2), p.389-393</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-bf3b5593da6e805f4773fc60ae7f10aeddb4933168c8e37216e383a2b2a83cc13</citedby><cites>FETCH-LOGICAL-c450t-bf3b5593da6e805f4773fc60ae7f10aeddb4933168c8e37216e383a2b2a83cc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16530807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15708683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Langlois, Marie-Hélène</creatorcontrib><creatorcontrib>Montagut, Martine</creatorcontrib><creatorcontrib>Dubost, Jean-Pierre</creatorcontrib><creatorcontrib>Grellet, Jean</creatorcontrib><creatorcontrib>Saux, Marie-Claude</creatorcontrib><title>Protonation equilibrium and lipophilicity of moxifloxacin</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in
n-octanol/buffer system which reached near
pI. The true partition coefficient was calculated from the log
P
app and microconstants values.</description><subject>1-Octanol</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Aza Compounds - chemistry</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Fluoroquinolones</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lipids - chemistry</subject><subject>Macroconstants</subject><subject>Medical sciences</subject><subject>Microconstants</subject><subject>Models, Chemical</subject><subject>Moxifloxacin</subject><subject>Octanol/buffer partition coefficients</subject><subject>Pharmacology. Drug treatments</subject><subject>Protons</subject><subject>Quinolines - chemistry</subject><subject>Solutions</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotlZfwIXMRndTc5lcCm6keIOCLhTchUwmwZSZyTSZkfbtzdBCd27OgZ_vPxw-AK4RnCOI2P16vu5KNccQFimYQ4xPwBQJTnLMiu9TMIWcoJxDQSfgIsY1hJCiRXEOJoimlAkyBYuP4Hvfqt75NjObwdWuDG5oMtVWWe063_2kSLt-l3mbNX7rbO23Srv2EpxZVUdzddgz8PX89Ll8zVfvL2_Lx1WuCwr7vLSkpHRBKsWMgNQWnBOrGVSGW5RmVZXFghDEhBaGcIyYIYIoXGIliNaIzMDd_m4X_GYwsZeNi9rUtWqNH6JkvMAU8RHEe1AHH2MwVnbBNSrsJIJyFCbXchQmR2FjloSl0s3h-lA2pjpWDoYScHsAVNSqtkG12sUjxyiBIomegYc9Z5KLX2eCjNqZVpvKBaN7WXn33x9_HqWJfQ</recordid><startdate>20050223</startdate><enddate>20050223</enddate><creator>Langlois, Marie-Hélène</creator><creator>Montagut, Martine</creator><creator>Dubost, Jean-Pierre</creator><creator>Grellet, Jean</creator><creator>Saux, Marie-Claude</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050223</creationdate><title>Protonation equilibrium and lipophilicity of moxifloxacin</title><author>Langlois, Marie-Hélène ; Montagut, Martine ; Dubost, Jean-Pierre ; Grellet, Jean ; Saux, Marie-Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-bf3b5593da6e805f4773fc60ae7f10aeddb4933168c8e37216e383a2b2a83cc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>1-Octanol</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Aza Compounds - chemistry</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Fluoroquinolones</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lipids - chemistry</topic><topic>Macroconstants</topic><topic>Medical sciences</topic><topic>Microconstants</topic><topic>Models, Chemical</topic><topic>Moxifloxacin</topic><topic>Octanol/buffer partition coefficients</topic><topic>Pharmacology. Drug treatments</topic><topic>Protons</topic><topic>Quinolines - chemistry</topic><topic>Solutions</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langlois, Marie-Hélène</creatorcontrib><creatorcontrib>Montagut, Martine</creatorcontrib><creatorcontrib>Dubost, Jean-Pierre</creatorcontrib><creatorcontrib>Grellet, Jean</creatorcontrib><creatorcontrib>Saux, Marie-Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langlois, Marie-Hélène</au><au>Montagut, Martine</au><au>Dubost, Jean-Pierre</au><au>Grellet, Jean</au><au>Saux, Marie-Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protonation equilibrium and lipophilicity of moxifloxacin</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2005-02-23</date><risdate>2005</risdate><volume>37</volume><issue>2</issue><spage>389</spage><epage>393</epage><pages>389-393</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in
n-octanol/buffer system which reached near
pI. The true partition coefficient was calculated from the log
P
app and microconstants values.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15708683</pmid><doi>10.1016/j.jpba.2004.10.022</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2005-02, Vol.37 (2), p.389-393 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | Elsevier |
| subjects | 1-Octanol Analysis Analytical, structural and metabolic biochemistry Aza Compounds - chemistry Biological and medical sciences Buffers Fluoroquinolones Fundamental and applied biological sciences. Psychology General pharmacology Hydrogen-Ion Concentration Lipids - chemistry Macroconstants Medical sciences Microconstants Models, Chemical Moxifloxacin Octanol/buffer partition coefficients Pharmacology. Drug treatments Protons Quinolines - chemistry Solutions Spectrophotometry, Ultraviolet |
| title | Protonation equilibrium and lipophilicity of moxifloxacin |
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