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Evaluation of wound healing activity of root of Mimosa pudica
Mimosa pudica, commonly known as touch-me-not, is used in folklore medicine in arresting bleeding and in skin diseases. There was no scientific evidence justifying the use of Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant. In the present stu...
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| Published in: | Journal of ethnopharmacology 2009-07, Vol.124 (2), p.311-315 |
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| cited_by | cdi_FETCH-LOGICAL-c471t-87ecfa5a048f2bfad59618684159da0ea4cdf6ec4ec683773ee0fdffafb9ee373 |
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| cites | cdi_FETCH-LOGICAL-c471t-87ecfa5a048f2bfad59618684159da0ea4cdf6ec4ec683773ee0fdffafb9ee373 |
| container_end_page | 315 |
| container_issue | 2 |
| container_start_page | 311 |
| container_title | Journal of ethnopharmacology |
| container_volume | 124 |
| creator | Kokane, Dnyaneshwar D. More, Rahul Y. Kale, Mandar B. Nehete, Minakshi N. Mehendale, Prachi C. Gadgoli, Chhaya H. |
| description | Mimosa pudica, commonly known as touch-me-not, is used in folklore medicine in arresting bleeding and in skin diseases.
There was no scientific evidence justifying the use of
Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant.
In the present study the roots of
Mimosa pudica were studied for wound healing activity by incorporating the methanolic and the total aqueous extract in simple ointment base B.P. in concentration of 0.5% (w/w), 1% (w/w) and 2% (w/w). Wound healing activity was studied in three types of model in rats viz. excision, incision and estimation of biochemical parameter. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model was evaluated by determining tensile strength and hydroxyproline content in the scab.
Treatment of wound with ointment containing 2% (w/w) the methanolic and 2% (w/w) the total aqueous extract exhibited significant (
P
<
0.001) wound healing activity. The methanolic and total aqueous extracts were analyzed for total phenols content equivalent to Gallic acid. The content of total phenols was 11% (w/w) and 17% (w/w) in methanolic and total aqueous extract respectively.
The methanolic extract exhibited good wound healing activity probably due to phenols constituents. |
| doi_str_mv | 10.1016/j.jep.2009.04.038 |
| format | article |
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There was no scientific evidence justifying the use of
Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant.
In the present study the roots of
Mimosa pudica were studied for wound healing activity by incorporating the methanolic and the total aqueous extract in simple ointment base B.P. in concentration of 0.5% (w/w), 1% (w/w) and 2% (w/w). Wound healing activity was studied in three types of model in rats viz. excision, incision and estimation of biochemical parameter. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model was evaluated by determining tensile strength and hydroxyproline content in the scab.
Treatment of wound with ointment containing 2% (w/w) the methanolic and 2% (w/w) the total aqueous extract exhibited significant (
P
<
0.001) wound healing activity. The methanolic and total aqueous extracts were analyzed for total phenols content equivalent to Gallic acid. The content of total phenols was 11% (w/w) and 17% (w/w) in methanolic and total aqueous extract respectively.
The methanolic extract exhibited good wound healing activity probably due to phenols constituents.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.04.038</identifier><identifier>PMID: 19397984</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Cutaneous ; Alkaloids - analysis ; animal models ; Animals ; Biological and medical sciences ; dosage ; dose response ; Excision ; Female ; gallic acid ; General pharmacology ; Hydroxyproline - metabolism ; Incision ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Mimosa - chemistry ; Mimosa pudica ; nursery crops ; Ointments ; ornamental plants ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenolic compounds ; Phenols ; Phenols - analysis ; Phytotherapy ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Rats ; roots ; Skin - drug effects ; Tannins - analysis ; tensile strength ; tissue repair ; Wound healing ; Wound Healing - drug effects ; Wounds and Injuries - drug therapy</subject><ispartof>Journal of ethnopharmacology, 2009-07, Vol.124 (2), p.311-315</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-87ecfa5a048f2bfad59618684159da0ea4cdf6ec4ec683773ee0fdffafb9ee373</citedby><cites>FETCH-LOGICAL-c471t-87ecfa5a048f2bfad59618684159da0ea4cdf6ec4ec683773ee0fdffafb9ee373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21731470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19397984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kokane, Dnyaneshwar D.</creatorcontrib><creatorcontrib>More, Rahul Y.</creatorcontrib><creatorcontrib>Kale, Mandar B.</creatorcontrib><creatorcontrib>Nehete, Minakshi N.</creatorcontrib><creatorcontrib>Mehendale, Prachi C.</creatorcontrib><creatorcontrib>Gadgoli, Chhaya H.</creatorcontrib><title>Evaluation of wound healing activity of root of Mimosa pudica</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Mimosa pudica, commonly known as touch-me-not, is used in folklore medicine in arresting bleeding and in skin diseases.
There was no scientific evidence justifying the use of
Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant.
In the present study the roots of
Mimosa pudica were studied for wound healing activity by incorporating the methanolic and the total aqueous extract in simple ointment base B.P. in concentration of 0.5% (w/w), 1% (w/w) and 2% (w/w). Wound healing activity was studied in three types of model in rats viz. excision, incision and estimation of biochemical parameter. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model was evaluated by determining tensile strength and hydroxyproline content in the scab.
Treatment of wound with ointment containing 2% (w/w) the methanolic and 2% (w/w) the total aqueous extract exhibited significant (
P
<
0.001) wound healing activity. The methanolic and total aqueous extracts were analyzed for total phenols content equivalent to Gallic acid. The content of total phenols was 11% (w/w) and 17% (w/w) in methanolic and total aqueous extract respectively.
The methanolic extract exhibited good wound healing activity probably due to phenols constituents.</description><subject>Administration, Cutaneous</subject><subject>Alkaloids - analysis</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>dosage</subject><subject>dose response</subject><subject>Excision</subject><subject>Female</subject><subject>gallic acid</subject><subject>General pharmacology</subject><subject>Hydroxyproline - metabolism</subject><subject>Incision</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mimosa - chemistry</subject><subject>Mimosa pudica</subject><subject>nursery crops</subject><subject>Ointments</subject><subject>ornamental plants</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenolic compounds</subject><subject>Phenols</subject><subject>Phenols - analysis</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Rats</subject><subject>roots</subject><subject>Skin - drug effects</subject><subject>Tannins - analysis</subject><subject>tensile strength</subject><subject>tissue repair</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and Injuries - drug therapy</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kMFu1DAQhi1ERZfCA3CBXOC2YRw7sSPUA6oKrdSKA_Rszdrj4lU2XuxkUd8eR7uCG6f_MN_M_PoYe8Oh5sC7j9t6S_u6AehrkDUI_YytuFbNWrVKPGcrEEqvtZL8nL3MeQsAikt4wc55L3rVa7lil9cHHGacQhyr6KvfcR5d9ZNwCONjhXYKhzA9LZMU47TkfdjFjNV-dsHiK3bmccj0-pQX7OHL9Y-rm_Xdt6-3V5_v1lYqPpUKZD22CFL7ZuPRtX3Hdaclb3uHQCit8x1ZSbbTQilBBN55j37TEwklLtiH4919ir9mypPZhWxpGHCkOGfTKdl0rRYF5EfQpphzIm_2KewwPRkOZnFmtqY4M4szA9IUZ2Xn7en4vNmR-7dxklSA9ycAs8XBJxxtyH-5hivBpYLCvTtyHqPBx1SYh-8NcFH-ttCIhfh0JKjIOgRKJttAoyUXEtnJuBj-U_QPI6qTRg</recordid><startdate>20090715</startdate><enddate>20090715</enddate><creator>Kokane, Dnyaneshwar D.</creator><creator>More, Rahul Y.</creator><creator>Kale, Mandar B.</creator><creator>Nehete, Minakshi N.</creator><creator>Mehendale, Prachi C.</creator><creator>Gadgoli, Chhaya H.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090715</creationdate><title>Evaluation of wound healing activity of root of Mimosa pudica</title><author>Kokane, Dnyaneshwar D. ; More, Rahul Y. ; Kale, Mandar B. ; Nehete, Minakshi N. ; Mehendale, Prachi C. ; Gadgoli, Chhaya H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-87ecfa5a048f2bfad59618684159da0ea4cdf6ec4ec683773ee0fdffafb9ee373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Cutaneous</topic><topic>Alkaloids - analysis</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>dosage</topic><topic>dose response</topic><topic>Excision</topic><topic>Female</topic><topic>gallic acid</topic><topic>General pharmacology</topic><topic>Hydroxyproline - metabolism</topic><topic>Incision</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mimosa - chemistry</topic><topic>Mimosa pudica</topic><topic>nursery crops</topic><topic>Ointments</topic><topic>ornamental plants</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenolic compounds</topic><topic>Phenols</topic><topic>Phenols - analysis</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Rats</topic><topic>roots</topic><topic>Skin - drug effects</topic><topic>Tannins - analysis</topic><topic>tensile strength</topic><topic>tissue repair</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokane, Dnyaneshwar D.</creatorcontrib><creatorcontrib>More, Rahul Y.</creatorcontrib><creatorcontrib>Kale, Mandar B.</creatorcontrib><creatorcontrib>Nehete, Minakshi N.</creatorcontrib><creatorcontrib>Mehendale, Prachi C.</creatorcontrib><creatorcontrib>Gadgoli, Chhaya H.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokane, Dnyaneshwar D.</au><au>More, Rahul Y.</au><au>Kale, Mandar B.</au><au>Nehete, Minakshi N.</au><au>Mehendale, Prachi C.</au><au>Gadgoli, Chhaya H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of wound healing activity of root of Mimosa pudica</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-07-15</date><risdate>2009</risdate><volume>124</volume><issue>2</issue><spage>311</spage><epage>315</epage><pages>311-315</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Mimosa pudica, commonly known as touch-me-not, is used in folklore medicine in arresting bleeding and in skin diseases.
There was no scientific evidence justifying the use of
Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant.
In the present study the roots of
Mimosa pudica were studied for wound healing activity by incorporating the methanolic and the total aqueous extract in simple ointment base B.P. in concentration of 0.5% (w/w), 1% (w/w) and 2% (w/w). Wound healing activity was studied in three types of model in rats viz. excision, incision and estimation of biochemical parameter. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model was evaluated by determining tensile strength and hydroxyproline content in the scab.
Treatment of wound with ointment containing 2% (w/w) the methanolic and 2% (w/w) the total aqueous extract exhibited significant (
P
<
0.001) wound healing activity. The methanolic and total aqueous extracts were analyzed for total phenols content equivalent to Gallic acid. The content of total phenols was 11% (w/w) and 17% (w/w) in methanolic and total aqueous extract respectively.
The methanolic extract exhibited good wound healing activity probably due to phenols constituents.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19397984</pmid><doi>10.1016/j.jep.2009.04.038</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2009-07, Vol.124 (2), p.311-315 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Administration, Cutaneous Alkaloids - analysis animal models Animals Biological and medical sciences dosage dose response Excision Female gallic acid General pharmacology Hydroxyproline - metabolism Incision Male Medical sciences medicinal plants medicinal properties Mimosa - chemistry Mimosa pudica nursery crops Ointments ornamental plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Phenols Phenols - analysis Phytotherapy plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Rats roots Skin - drug effects Tannins - analysis tensile strength tissue repair Wound healing Wound Healing - drug effects Wounds and Injuries - drug therapy |
| title | Evaluation of wound healing activity of root of Mimosa pudica |
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