Synthesis, characterization and DNA binding studies of a zinc complex with 2,6-bis(benzimidazol-2-yl) pyridine

A zinc(II) complex having planar tridentate ligand, bzimpy, where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by UV, NMR, infrared spectroscopy and fluorescence spectra. The zinc complex acts as dibasic acids, in which N–H protons on benzimidazole moieties are res...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2005-03, Vol.99 (3), p.883-885
Main Authors: Wang, Jiaoliang, Shuai, Li, Xiao, Xiaoming, Zeng, Yue, Li, Zelin, Matsumura-Inoue, Takeko
Format: Article
Language:English
Subjects:
2,6-Bis(benzimidazol-2-yl) pyridine
Base Pairing
Benzimidazoles - chemistry
DNA - drug effects
DNA - metabolism
DNA binding
Intercalating Agents - chemical synthesis
Intercalating Agents - pharmacology
Ligands
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - pharmacology
Protons
Pyridines - chemistry
Spectrum Analysis
Zinc - chemistry
Zinc complex
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Summary:A zinc(II) complex having planar tridentate ligand, bzimpy, where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by UV, NMR, infrared spectroscopy and fluorescence spectra. The zinc complex acts as dibasic acids, in which N–H protons on benzimidazole moieties are responsible for a deprotonation site. Both the absorption spectra and reduction potentials are strongly dependent on the solution pH, which leads to the basis of a proton-induced molecular switch. The binding of this complex with calf thymus DNA has been investigated by absorption, luminescence titrations and viscosity measurements. The results suggest that the zinc(II) complex intercalates into DNA base pairs via the ligand bzimp.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2004.12.018