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Correction of motion artifact in cardiac optical mapping using image registration

Cardiac motion is one of the main sources of artifacts in epifluorescence imaging experiments. It can cause significant error in electrophysiological measurements such as action potential duration. We present a novel approach that uses image registration based on maximization of mutual information t...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2005-02, Vol.52 (2), p.338-341
Main Authors: Rohde, G.K., Dawant, B.M., Shien-Fong Lin
Format: Article
Language:English
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Summary:Cardiac motion is one of the main sources of artifacts in epifluorescence imaging experiments. It can cause significant error in electrophysiological measurements such as action potential duration. We present a novel approach that uses image registration based on maximization of mutual information to correct for in-plane cardiac motion in such experiments. The approach is relatively fast (a few seconds per frame) and is performed entirely post acquisition. The image registration approach is an alternative to traditional approaches such as mechanical restraint of the heart or addition of chemical uncouplers. Our results show that the image registration method significantly reduces motion-related artifacts in experimental data.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2004.840464