High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors

Background: Thrombophilia refers to series of acquired and inherited conditions that confer a tendency to thrombus formation. The exact relationship between thrombophilia and MI is not well established. Objectives: To determine the prevalence of thrombophilia in young patients with their first MI an...

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Bibliographic Details
Published in:International journal of cardiology 2005-02, Vol.98 (3), p.421-424
Main Authors: Segev, Amit, Ellis, Martin H., Segev, Fani, Friedman, Ziva, Reshef, Tamar, Sparkes, John D., Tetro, Jana, Pauzner, Hana, David, Daniel
Format: Article
Language:English
Subjects:
Adult
Antibodies, Anticardiolipin - analysis
Biological and medical sciences
Cardiology. Vascular system
Comorbidity
Coronary heart disease
Factor V - analysis
Female
Heart
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Myocardial infarction
Myocardial Infarction - epidemiology
Myocarditis. Cardiomyopathies
Platelet diseases and coagulopathies
Regression Analysis
Risk Factors
Thrombophilia
Thrombophilia - blood
Thrombophilia - epidemiology
Young patients
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Summary:Background: Thrombophilia refers to series of acquired and inherited conditions that confer a tendency to thrombus formation. The exact relationship between thrombophilia and MI is not well established. Objectives: To determine the prevalence of thrombophilia in young patients with their first MI and few conventional risk factors. Methods: We evaluated the baseline characteristics and the thrombophilia profile, including anti-cardiolipin antibodies, activated protein C resistance (APCR) with the factor V Leiden mutation, prothrombin G20210A mutation, protein C, protein S, and antithrombin-III levels, among 85 consecutive patients (
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.10.057