High flow nasal cannula therapy as respiratory support in the preterm infant

We reviewed the literature on the effects of high flow nasal cannula (HFNC) and heated, humidified, high‐flow, nasal cannula (HHHFNC) treatment in preterm infants. We found nine studies, but only two were randomized controlled trials. These studies show that: HFNC application is associated to the de...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric pulmonology 2009-07, Vol.44 (7), p.629-634
Main Authors: Dani, Carlo, Pratesi, Simone, Migliori, Claudio, Bertini, Giovanna
Format: Article
Language:English
Subjects:
Biological and medical sciences
Continuous Positive Airway Pressure
Diseases of mother, fetus and pregnancy
General aspects
Gynecology. Andrology. Obstetrics
high flow nasal cannula
Humans
Humidity
infant
Infant, Newborn
Infant, Premature
Intubation, Intratracheal
Medical sciences
oxygen delivery
Oxygen Inhalation Therapy - instrumentation
Oxygen Inhalation Therapy - methods
Pneumology
Pregnancy. Fetus. Placenta
Respiration, Artificial
Respiratory Distress Syndrome, Newborn - therapy
Ventilator Weaning
Work of Breathing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We reviewed the literature on the effects of high flow nasal cannula (HFNC) and heated, humidified, high‐flow, nasal cannula (HHHFNC) treatment in preterm infants. We found nine studies, but only two were randomized controlled trials. These studies show that: HFNC application is associated to the delivery of continuous distending pressure (CDP) in patients with closed mouth, whose value is proportional to the delivered flow only in smaller infants; the CDP delivered by HFNC is unpredictable and present large inter‐patient and intra‐patient variability; the use of recently available HHHFNC devices is effective in minimizing nasal mucosa injuries compared to traditional HFNC; the effectiveness of HHHFNC versus NCPAP for the treatment of apnoea of prematurity, respiratory distress syndrome, and the prevention of extubation failure, has been poor investigated and firm conclusions cannot be drawn on this matter. In conclusion, on the basis of published data, the routinary application of HFNC should be limited to patients requiring oxygen‐therapy, HHHFNC devices should be preferred to HFNC, but their employment as an alternative to NCPAP should wait for the conclusion of randomized controlled trials. Pediatr Pulmonol. 2009; 44:629–634. © 2009 Wiley‐Liss, Inc.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.21051