Detection of prostate specific transcripts in the peripheral blood during brachytherapy predicts postoperative PSA kinetics

BACKGROUND We evaluated whether detection of prostate‐specific antigen (PSA) and human kallikrein 2 (hK2) transcripts in the peripheral blood during brachytherapy could predict biochemical outcome. METHODS Eighty‐one patients who underwent 125Iodine‐based brachytherapy for localized prostate cancer...

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Bibliographic Details
Published in:The Prostate 2009-08, Vol.69 (11), p.1235-1244
Main Authors: Mabjeesh, Nicola J., Amir, Sharon, Stenger, Amira, Chen, Juza, Matzkin, Haim
Format: Article
Language:English
Subjects:
Aged
Androgens - metabolism
Biomarkers, Tumor - blood
Brachytherapy
Follow-Up Studies
hK2
Humans
Male
Middle Aged
peripheral blood
Postoperative Period
Predictive Value of Tests
Prognosis
prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - radiotherapy
PSA
RNA, Messenger - blood
RT-PCR
Tissue Kallikreins - blood
Treatment Outcome
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Summary:BACKGROUND We evaluated whether detection of prostate‐specific antigen (PSA) and human kallikrein 2 (hK2) transcripts in the peripheral blood during brachytherapy could predict biochemical outcome. METHODS Eighty‐one patients who underwent 125Iodine‐based brachytherapy for localized prostate cancer (Gleason score
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.20977