High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia

Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clon...

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Bibliographic Details
Published in:Blood 2005-03, Vol.105 (5), p.2138-2140
Main Authors: Ferraris, Anna Maria, Mangerini, Rosa, Pujic, Natalija, Racchi, Omar, Rapezzi, Davide, Gallamini, Andrea, Casciaro, Salvatore, Gaetani, Gian Franco
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Clone Cells
Dosage Compensation, Genetic
Female
Granulocytes - metabolism
Granulocytes - pathology
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytes, Mononuclear - metabolism
Medical sciences
Middle Aged
Platelet diseases and coagulopathies
Polycythemia Vera - genetics
Polycythemia Vera - pathology
Prognosis
Telomerase - metabolism
Thrombocythemia, Essential - genetics
Thrombocythemia, Essential - pathology
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Summary:Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2004-06-2375