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High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia
Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clon...
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| Published in: | Blood 2005-03, Vol.105 (5), p.2138-2140 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c428t-fe2de304e3ad8a9e5313cb20c85d4c9c1b35b4aa3f048dca26258c813040a67a3 |
| container_end_page | 2140 |
| container_issue | 5 |
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| container_title | Blood |
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| creator | Ferraris, Anna Maria Mangerini, Rosa Pujic, Natalija Racchi, Omar Rapezzi, Davide Gallamini, Andrea Casciaro, Salvatore Gaetani, Gian Franco |
| description | Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors. |
| doi_str_mv | 10.1182/blood-2004-06-2375 |
| format | article |
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On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2004-06-2375</identifier><identifier>PMID: 15494424</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Clone Cells ; Dosage Compensation, Genetic ; Female ; Granulocytes - metabolism ; Granulocytes - pathology ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes, Mononuclear - metabolism ; Medical sciences ; Middle Aged ; Platelet diseases and coagulopathies ; Polycythemia Vera - genetics ; Polycythemia Vera - pathology ; Prognosis ; Telomerase - metabolism ; Thrombocythemia, Essential - genetics ; Thrombocythemia, Essential - pathology</subject><ispartof>Blood, 2005-03, Vol.105 (5), p.2138-2140</ispartof><rights>2005 American Society of Hematology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-fe2de304e3ad8a9e5313cb20c85d4c9c1b35b4aa3f048dca26258c813040a67a3</citedby><cites>FETCH-LOGICAL-c428t-fe2de304e3ad8a9e5313cb20c85d4c9c1b35b4aa3f048dca26258c813040a67a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000649712045829X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3538,27907,27908,45763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16944130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15494424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferraris, Anna Maria</creatorcontrib><creatorcontrib>Mangerini, Rosa</creatorcontrib><creatorcontrib>Pujic, Natalija</creatorcontrib><creatorcontrib>Racchi, Omar</creatorcontrib><creatorcontrib>Rapezzi, Davide</creatorcontrib><creatorcontrib>Gallamini, Andrea</creatorcontrib><creatorcontrib>Casciaro, Salvatore</creatorcontrib><creatorcontrib>Gaetani, Gian Franco</creatorcontrib><title>High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia</title><title>Blood</title><addtitle>Blood</addtitle><description>Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Clone Cells</subject><subject>Dosage Compensation, Genetic</subject><subject>Female</subject><subject>Granulocytes - metabolism</subject><subject>Granulocytes - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet diseases and coagulopathies</subject><subject>Polycythemia Vera - genetics</subject><subject>Polycythemia Vera - pathology</subject><subject>Prognosis</subject><subject>Telomerase - metabolism</subject><subject>Thrombocythemia, Essential - genetics</subject><subject>Thrombocythemia, Essential - pathology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kE1vEzEQhi0EomnhD3BAvsBty_hjNxuJC4pKW6kSFzhbs_ZsY-RdB9uJlH9fh6TqraeRZp53NPMw9knAtRC9_DaEGF0jAXQDXSPVsn3DFqKVfQMg4S1bANS-Xi3FBbvM-S-A0Eq279mFaPVKa6kXzN35xw0vFOJECTNxtMXvfTlwP_PHhPMuRHsolPmY4sRtiDMGvo3hULsbmjzyfQ1ynB2nnGkuvs7LpsJDfEY-sHcjhkwfz_WK_fl583t91zz8ur1f_3horJZ9aUaSjhRoUuh6XFGrhLKDBNu3TtuVFYNqB42oRtC9syg72fa2FzUC2C1RXbGvp73bFP_tKBcz-WwpBJwp7rLpllodX6-gPIE2xZwTjWab_ITpYASYo1vz3605ujXQmaPbGvp83r4bJnIvkbPMCnw5A5gthrHasz6_cF3F6rGV-37iqLrYe0omW0-zJecT2WJc9K_d8QTjHpmt</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Ferraris, Anna Maria</creator><creator>Mangerini, Rosa</creator><creator>Pujic, Natalija</creator><creator>Racchi, Omar</creator><creator>Rapezzi, Davide</creator><creator>Gallamini, Andrea</creator><creator>Casciaro, Salvatore</creator><creator>Gaetani, Gian Franco</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia</title><author>Ferraris, Anna Maria ; Mangerini, Rosa ; Pujic, Natalija ; Racchi, Omar ; Rapezzi, Davide ; Gallamini, Andrea ; Casciaro, Salvatore ; Gaetani, Gian Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-fe2de304e3ad8a9e5313cb20c85d4c9c1b35b4aa3f048dca26258c813040a67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Clone Cells</topic><topic>Dosage Compensation, Genetic</topic><topic>Female</topic><topic>Granulocytes - metabolism</topic><topic>Granulocytes - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet diseases and coagulopathies</topic><topic>Polycythemia Vera - genetics</topic><topic>Polycythemia Vera - pathology</topic><topic>Prognosis</topic><topic>Telomerase - metabolism</topic><topic>Thrombocythemia, Essential - genetics</topic><topic>Thrombocythemia, Essential - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraris, Anna Maria</creatorcontrib><creatorcontrib>Mangerini, Rosa</creatorcontrib><creatorcontrib>Pujic, Natalija</creatorcontrib><creatorcontrib>Racchi, Omar</creatorcontrib><creatorcontrib>Rapezzi, Davide</creatorcontrib><creatorcontrib>Gallamini, Andrea</creatorcontrib><creatorcontrib>Casciaro, Salvatore</creatorcontrib><creatorcontrib>Gaetani, Gian Franco</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferraris, Anna Maria</au><au>Mangerini, Rosa</au><au>Pujic, Natalija</au><au>Racchi, Omar</au><au>Rapezzi, Davide</au><au>Gallamini, Andrea</au><au>Casciaro, Salvatore</au><au>Gaetani, Gian Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>105</volume><issue>5</issue><spage>2138</spage><epage>2140</epage><pages>2138-2140</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>15494424</pmid><doi>10.1182/blood-2004-06-2375</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Blood, 2005-03, Vol.105 (5), p.2138-2140 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Clone Cells Dosage Compensation, Genetic Female Granulocytes - metabolism Granulocytes - pathology Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes, Mononuclear - metabolism Medical sciences Middle Aged Platelet diseases and coagulopathies Polycythemia Vera - genetics Polycythemia Vera - pathology Prognosis Telomerase - metabolism Thrombocythemia, Essential - genetics Thrombocythemia, Essential - pathology |
| title | High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia |
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