Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We pro...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-03, Vol.160 (1), p.228-232
Main Authors: Boscolo, S., Baldas, V., Gobbi, G., Giordano, L., Cioni, G., Not, T., Ventura, A., Tongiorgi, E.
Format: Article
Language:English
Subjects:
Adolescent
Animals
Anti-brain autoantibodies
Autoantibodies - analysis
Autoantibodies - biosynthesis
Autoimmunity
Brain Chemistry - immunology
Brain Stem - immunology
Celiac Disease - immunology
Cerebellum - immunology
Cerebral Cortex - immunology
Child
Child, Preschool
Epilepsy - immunology
Humans
Landau-Kleffner Syndrome - immunology
Pediatric epilepsy
Purkinje Cells - immunology
Rats
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Summary:The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2004.10.031