Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood

OBJECTIVE: To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS). DESIGN AND SUBJECTS: Subcutaneous, mesenterial and omental adip...

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Bibliographic Details
Published in:International Journal of Obesity 2005-03, Vol.29 (3), p.275-280
Main Authors: Knerr, I, Schirl, C, Horbach, T, Stuppy, A, Carbon, R, Rascher, W, Dötsch, J
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Adipose Tissue - metabolism
Adolescent
Adrenomedullin
Adult
Adults
Aged
Aging - metabolism
Biological and medical sciences
Body fat
Body Mass Index
Body weight
Child
Child, Preschool
Endocrine disorders
Endothelin-1 - genetics
Endothelin-1 - metabolism
Epidemiology
Female
Gene expression
Gene Expression Regulation, Developmental
Health Promotion and Disease Prevention
Humans
Infant
Infectious diseases
Insulin
Internal Medicine
Laparotomy
Male
Medical sciences
Medicine
Medicine & Public Health
Mesentery - metabolism
Metabolic Diseases
Metabolism
Middle Aged
Nitric oxide
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Obesity
Omentum - metabolism
Peptides
Peptides - genetics
Peptides - metabolism
Physiology
Public Health
RNA, Messenger - genetics
Subcutaneous Tissue - metabolism
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Summary:OBJECTIVE: To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS). DESIGN AND SUBJECTS: Subcutaneous, mesenterial and omental adipose tissue specimens taken from 15 children (age 0.5–16 y, median 6 y) and 13 adults (age 43–79 y, median 60 y) were analyzed. The body mass indices (BMI) were within the normal range. All patients were normotensive, and were free of infectious disease, and metabolic or endocrine disorders. The specimens were taken during elective laparotomies after informed consent was obtained. MEASUREMENTS: ADM, ET-1, the endothelial (eNOS) and inducible (iNOS) NOS as well as two housekeeping genes were measured using quantitative real-time PCR. RESULTS: ADM gene expression was found at all locations, and was significantly higher in adults than in children ( P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802885