The Natural Course of Chlamydia trachomatis Infection in Asymptomatic Colombian Women: A 5-Year Follow-Up Study

The natural course of Chlamydia trachomatis infection and its risk factors were studied in Colombian women with normal cytological results, during a 5-year period. Eighty-two women who were found to be positive for C. trachomatis at the start of the study were studied at 6-month intervals. At each v...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-03, Vol.191 (6), p.907-916
Main Authors: Molano, Mónica, Meijer, Chris J. L. M., Weiderpass, Elisabete, Arslan, Annie, Posso, Hector, Franceschi, Silvia, Ronderos, Margarita, Muñoz, Nubia, van den Brule, Adriaan J. C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibiotics
Bacteria
Bacteriology
Biological and medical sciences
Cervix Uteri - microbiology
Chlamydia Infections - immunology
Chlamydia Infections - microbiology
Chlamydia Infections - physiopathology
Chlamydia trachomatis
Chlamydia trachomatis - classification
Chlamydia trachomatis - genetics
Chlamydia trachomatis - isolation & purification
Colombia
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
Immunoenzyme Techniques
Infections
Infectious diseases
Intrauterine devices
Medical sciences
Microbiology
Miscellaneous
Oral contraceptives
Plasmids
Plasmids - genetics
Polymerase chain reaction
Polymerase Chain Reaction - methods
Predisposing factors
Risk Factors
Serotyping
Sex education
Sexual intercourse
Specimen Handling - methods
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Summary:The natural course of Chlamydia trachomatis infection and its risk factors were studied in Colombian women with normal cytological results, during a 5-year period. Eighty-two women who were found to be positive for C. trachomatis at the start of the study were studied at 6-month intervals. At each visit, a cervical scrape sample was obtained for detection of C. trachomatis by use of C. trachomatis endogenous-plasmid polymerase chain reaction (PCR)–enzyme immunoassay and VD2-PCR–reverse line blot assay. Of the women studied, 67% had a single-serovar infection, 10% had a mixed-serovar infection, and 23% had an infection with an unidentified type. An inversed rate of clearance of C. trachomatis infection was observed with oral contraceptive use (hazard ratio [HR], 1.7 [95% confidence interval {CI}, 1.1–2.7]) and first sexual intercourse at ⩾20 years of age (HR, 4.3 [95% CI, 2.3–8.0]). Serovars of group B (B, D, and E) and C (H, I, J, and K) had a decreased rate of clearance (rate ratio, 0.4 [95% CI, 0.1–0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections
ISSN:0022-1899
1537-6613
DOI:10.1086/428287